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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Study period:
01-March 1979 - 10-April 1979
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Non-GLP study. No guideline followed.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1979
Report Date:
1979

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
rats; 10 females per dose group, SC injection of MCAA in water; 4 dose levels; necropsy
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
monochloressigsaure VA 2308

Test animals

Species:
rat
Strain:
Wistar
Sex:
female
Details on test animals and environmental conditions:
no data

Administration / exposure

Route of administration:
subcutaneous
Vehicle:
other: 0.9% saline
Details on exposure:
subcutaneous
Doses:
80, 100, 125, 200, 315 mg/kg
No. of animals per sex per dose:
10 females per dose group
Control animals:
no
Details on study design:
not specified
Statistics:
probitanalyse (methode nach Linder and Weber)
95%CL according to Cavelli-Sforza

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LC50
Effect level:
ca. 97.4
Based on:
test mat.
95% CL:
>= 89.9 - <= 105.5
Mortality:
80 mg/kg 1/10
100 mg/kg 5/10
125 mg/kg 10/10
200 mg/kg 10/10
315 mg/kg 10/10
Clinical signs:
hunched posture, piloerection, ptosis, lethargy, uncoordinated movements, tremor, salivation, quick breathing, laboured breathing
Body weight:
no data
Gross pathology:
Brown discoloration of the liver and strong vasculated liver, red jejunum.
Treatment area grey-brown discoloration of the dermis and muscle.
Other findings:
no data

Any other information on results incl. tables

none

Applicant's summary and conclusion

Conclusions:
LD50 97.4 mg/kg in females
95%CL 89.9-105.5 mg/kg