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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Study period:
01-29 march 1979
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: According to the guideline, however GLP information is not available

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1979
Report Date:
1979

Materials and methods

Test guidelineopen allclose all
Guideline:
other: not mentioned
Qualifier:
equivalent or similar to
Guideline:
EU Method B.1 (Acute Toxicity (Oral))
Deviations:
not specified
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Monochloressigsaure VM 2308

Test animals

Species:
rat
Strain:
Wistar
Sex:
female
Details on test animals and environmental conditions:
no data

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Details on oral exposure:
VEHICLE
- Concentration in vehicle: 1%
MAXIMUM DOSE VOLUME APPLIED:max 16 ml/kg
Doses:
40 mg/kg
63 mg/kg
100 mg/kg
160 mg/kg
No. of animals per sex per dose:
10
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: weekly weighing and no data on observation scheme
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, macroscopic examination
Statistics:
no data

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
>= 90.4 mg/kg bw
Based on:
test mat.
95% CL:
>= 73.6 - <= 112
Mortality:
40 mg/kg 0/10
63 mg/kg 2/10
100 mg/kg 5/10
160 mg/kg 10/10
Clinical signs:
Animal which died during study: restless behaviour, uncoordinated movements, hunched posture, lethargy, lacrimation, piloerection, pulsing respiration,
suviving animals showed these symptoms at lower grade and recovered from all symptoms 48h after dosing.
Body weight:
normal
Gross pathology:
surviving animals : no findings
animals which died during the study showed: red-brown and highly vascularised liver with patch pattern, red-pink lungs with foci, Spleen was black discolorated on the stomach-side.

Applicant's summary and conclusion

Interpretation of results:
toxic
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
LD50= 90.4 mg/kg