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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: data reported in brief

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku
Author:
Marhold JV
Year:
1972
Bibliographic source:
Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, 1972 ,p.8
Reference Type:
review article or handbook
Title:
Potasium chloride. toxicity profile
Author:
BIBRA
Year:
1989
Bibliographic source:
The British Industrial Biological Research|Association, Carshalton, UK

Materials and methods

Principles of method if other than guideline:
Single dermal application to the skin of rabbits
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Potassium chloride
EC Number:
231-211-8
EC Name:
Potassium chloride
Cas Number:
7447-40-7
Molecular formula:
KCl
IUPAC Name:
potassium chloride
Details on test material:
no further data

Test animals

Species:
rabbit
Strain:
not specified

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
not specified
Controls:
not specified
Duration of treatment / exposure:
no data
Observation period:
no data
Number of animals:
no data

Results and discussion

In vivo

Results
Irritation parameter:
other: overall irritation
Basis:
mean
Time point:
other: no data
Score:
ca. 0
Max. score:
6
Reversibility:
other: not adequate
Remarks on result:
other: the substance was evaluated to be not irritating to the skin of rabbits
Irritant / corrosive response data:
the substance was evaluated to be practically not irritating to the skin of rabbit
Other effects:
no data

Applicant's summary and conclusion

Executive summary:

Potassium chloride was applied to the skin of rabbit and was evaluated as practically not irritating to the skin ( grade 0/6Marhold 1972).