Registration Dossier
Registration Dossier
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EC number: 231-211-8 | CAS number: 7447-40-7
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- other: case report
- Adequacy of study:
- supporting study
- Reliability:
- other:
- Rationale for reliability incl. deficiencies:
- other: case report
Data source
Reference
- Reference Type:
- publication
- Title:
- Fatal Hyperkalemia from accidental overdose of potassium chloride
- Author:
- Wetli ChV, Davis JH
- Year:
- 1 978
- Bibliographic source:
- JAMA 240, 1339
Materials and methods
- Study type:
- poisoning incident
- Endpoint addressed:
- acute toxicity: oral
- Principles of method if other than guideline:
- oral application of a total dose of 4500 mg KCl to a 2-month old baby in three portions
- GLP compliance:
- no
Test material
- Reference substance name:
- Potassium chloride
- EC Number:
- 231-211-8
- EC Name:
- Potassium chloride
- Cas Number:
- 7447-40-7
- Molecular formula:
- KCl
- IUPAC Name:
- potassium chloride
- Details on test material:
- no further data
Constituent 1
Method
- Subjects:
- 2-months old boy, 4.8 kg
- Route of exposure:
- oral
- Reason of exposure:
- intentional
- Exposure assessment:
- measured
Results and discussion
- Clinical signs:
- A few hours later the baby became cyanotic, stopped breathing and was rushed to a hospital. The initial serum potassium level was 10.1mEq/liter and remained elevated until the boy died 28 hours later
- Outcome of incidence:
- A 2 -month old 4.8 kg boy had collic.As adviced by a popular health book, The mother fed the baby wih 3000 mg KCL mixed with breast milk in two portions, the symptoms were relieved but recurred the next morning. The mother fed the baby again with 1500 mg KCl mixed in breast milk.
A few hours later the baby became cyanotic, stopped breathing and was rushed to a hospital. The initial serum potassium level was 10.1mEq/liter and remained elevated until the boy died 28 hours later
Applicant's summary and conclusion
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