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Administrative data

Link to relevant study record(s)

Description of key information

Key value for chemical safety assessment

EC10, LC10 or NOEC for freshwater invertebrates:
8.87 mg/L

Additional information

Read across on Sodium Valproate

Method: OECD Test Guideline 211 Data relate to another salt.

Species: Daphnia magna

Exposure duration: 21 d 

Reproduction per Survived Parent (Cumulative Offspring per Survived Parent):

21-day NOEC : ≥ 8.87 mg test item/L (time weighted average concentration); ≥ 10 mg test item/L (nominal concentrations)

21-day EC50 : > 8.87 mg test item/L (time weighted average concentration); > 10 mg test item/L (nominal concentrations)

21-day EC10 : > 8.87 mg test item/L (time weighted average concentration); > 10 mg test item/L (nominal concentrations)

Mortality:

21-day NOEC : ≥ 8.87 mg test item/L (time weighted average concentration); ≥ 10 mg test item/L (nominal concentrations)

21-day EC50 : > 8.87 mg test item/L (time weighted average concentration); > 10 mg test item/L (nominal concentrations)

Signs of Intoxication:

Apart from the reported mortality, dead offspring were observed during the test. According to the Guideline, these dead offspring are not considered in the evaluation of the results

10 mg/L was the highest tested dose.

Based on the read across on sodium valproate, valproic acid is expected to have a 21-day NOEC ≥ 8.87 mg test item/L and a 21-day EC50 : > 8.87 mg test item/L.