Registration Dossier

Physical & Chemical properties

Boiling point

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Administrative data

Endpoint:
boiling point
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2017
Report Date:
2017

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
OECD Guideline 103 (Boiling Point)
Qualifier:
according to
Guideline:
EU Method A.2 (Boiling Temperature)
GLP compliance:
no
Type of method:
differential scanning calorimetry

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Supplied by Parke-Davis Pharmaceutical Research Division
- The percentages of active component (valproic acid) were determined by a gas-chromatographic assay for purposes of dose calculation.

Results and discussion

Boiling point
Key result
Boiling pt.:
226.5 °C
Atm. press.:
99.67 kPa

Applicant's summary and conclusion

Conclusions:
Valproic acid has a boiling point of 226.5°C (temperature: 499.7 K, atmospheric pressure: 99.67 kPa)