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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation
Remarks:
in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Study period:
1955-11-05
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only short abstract available.

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1955

Materials and methods

Principles of method if other than guideline:
Skin sensitization was tested by a drop-on method in guinea pigs.
GLP compliance:
no
Type of study:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Triacetin
- Analytical purity: no data

In vivo test system

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified

Study design: in vivo (non-LLNA)

Inductionopen allclose all
Route:
other: epicutaneous drop on
Vehicle:
other: A:D: guinea pig fat
Concentration / amount:
0.1 M
Challengeopen allclose all
Route:
other: no data
Vehicle:
other: A:D: guinea pig fat
Concentration / amount:
0.1 M
No. of animals per dose:
5
Challenge controls:
Solvent controls were performed.
Positive control substance(s):
yes
Remarks:
Phenylhydrazine

Results and discussion

Any other information on results incl. tables

Table 1: Results of Sensitisation Test with Triacetin in Guinea Pigs

Solution

Number of guinea pigs tested

Type of Test

Final Score

24 h

48 h

0.1M Triacetin in A:D:Guinea Pig Fat

5

Drop-On

1.0

1.0

Solvent Control

3

Drop-On

1.2

1.0

Phenylhydrazine Control 0.1M in D:Guinea Pig Fat

3

Drop-On

3.2

3.7

Triacetin

5

Drop-On

0.5

0.1

1:1:3 A:D:Triacetin

5

Drop-On

0.4

0.1

4-Phenyl Catechol in A:D:Triacetin*

5

  

Drop-On

0.4*

0.5*

p-Phenyl diamine in

A:D:Triacetin*

5

  

Drop-On

0.3*

0.2*

 Possible explanation for: A:D: = Acetin - Diacetin (no explanation reported).

*Not a good oil to use because sensitisers do not react in it (Triacetin probably inhibited the sensitising effect of the positive control substances 4-Phenyl Catechol and p-Phenyl diamine).

Applicant's summary and conclusion

Interpretation of results:
not sensitising
Remarks:
Migrated information to guinea pig skin Criteria used for interpretation of results: expert judgment