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EC number: 905-964-4 | CAS number: -
NOEC (21 d) ≥ 94 mg/L for Daphnia magna (OECD 211)
Since no studies investigating the long-term toxicity to aquatic invertebrates of Reaction mixture of Glycerol 1,3- di(acetate), glycerol acetate and triacetin are available for this endpoint, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 a read-across to another structurally related substance triacetin was conducted. This read-across is justified in detail in the overall summary (IUCLID chapter 6.1) and within the analogue justification in IUCLID Section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was used for the assessment. As it can be seen in the data matrix of the analogue justification in section 13 and the overall summary, all reliable aquatic data support the read-across by showing a consistent pattern of results. The study was conducted according to OECD 211 under GLP conditions with the water flea Daphnia magna. A limit test with a concentration of 100 mg/L was chosen. After 21 d under semi-static conditions, no effects on the reproduction could be reported resulting in a NOEC of ≥ 94 mg/L (meas. geom. mean). Thus, taking this long-term result into account and considering also the acute results (LC50 (96 h) > 1000 mg/L (Scophthalmus maximus); EC50 (48 h) > 2000 mg/L (Acartia tonsa); NOEC (72 h) 100 mg/L (Skeletonema costatum)), no further data on long-term toxicity for Reaction mixture of Glycerol 1,3- di(acetate), glycerol acetate and triacetin are deemed necessary. Based on the results from a structurally related read-across substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which is characterized by a similar ecotoxicological profile, it can be concluded that Reaction mixture of Glycerol 1,3- di(acetate), glycerol acetate and triacetin will not exhibit chronic effects to aquatic invertebrates up to 100 mg/L.
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