Registration Dossier
Registration Dossier
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EC number: 918-139-9 | CAS number: 1228577-90-9
Endpoint summary
Administrative data
Description of key information
Additional information
96 hour EC50 (Brachydanio rerio) > 100 mg/l (nominal). No effects observed.
The 48 hour EC0 to Daphnia magna was reported as 84 mg/l (analytical).
The 21 day-NOEC in a OECD 211 guideline study (with Daphnia magna) is ≥ 10 mg/l (nominal) for all mortality and the 21 day-EC10 value is 2.5 mg/l (nominal) for reproduction.
72 hr EC0 growth rate (Desmodesmus subspicatus) > 100 mg/l (nominal). No effects were observed.
72 hr NOEC growth rate (Desmodesmus subspicatus) ≥ 100 mg/l (nominal).
3 hr EC50 respiration inhibition( activated sludge): ca. 10,000 mg/l.
3 hr EC10 respiration inhibition( activated sludge): ca. 1,800 mg/l.
Read-across statement
No-Longer-Polymer (NLP) polyether polyols are produced by the reaction of various starter molecules with propylene oxide and/or ethylene oxide. These substances exhibit a remarkable uniformity in the physical/chemical properties which influence their fate and distribution in the environment. All NLP polyols have a full acute aquatic ecotoxicity dataset and do not exhibit acute toxicity below 100 mg/L. However, differentiation in chronic invertebrate toxicity is apparent and is based on the alcohol- or amino- starter molecules used to prepare these NLP polyols. A sub-grouping based on (i) aliphatic alcohol and amine NLP polyols, (ii) EDA- (ethylenediamine) based amino NLP polyols and (iii) o-TDA- (orthodiaminotoluene) based aromatic NLP polyols is justified (ISOPA, 2010) and toxicity is expected to be similar between substances within each of these categories. It is considered appropriate to use ‘read-across’ of data of structural analogues within each sub-grouping to fill data gaps for chronic invertebrate toxicity and derive PNECs for endpoints based on these sub-groupings
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