Registration Dossier
Registration Dossier
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EC number: 249-978-2 | CAS number: 29964-84-9
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data are given.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Embryonic-Fetal Toxicity and Teratogenic Effects of a Group of Methacrylate Esters in Rats.
- Author:
- Singh AR, Lawrence WH, Autian J
- Year:
- 1 972
- Bibliographic source:
- Journal of Dental Research 51(6): 1632-1638
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 973
Materials and methods
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Isodecyl methacrylate
- EC Number:
- 249-978-2
- EC Name:
- Isodecyl methacrylate
- Cas Number:
- 29964-84-9
- Molecular formula:
- C14H26O2
- IUPAC Name:
- 2-methylnonyl 2-methylprop-2-enoate
- Details on test material:
- 2-Propenoic acid, 2-methyl-, isodecyl ester purity not specified, but commercial grade assumed.
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 2-Propenoic acid, 2-methyl, isodecylester (CAS: 29964-84-9) containing 100 ppm hydroquinone Density: 0.88 g/cm3 (20 degree C)
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
Administration / exposure
- Route of administration:
- intraperitoneal
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 2 171 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 1 035 - 4 551
- Remarks on result:
- other: Original value: 2.4666 ml/kg (1.1765 - 5.1712 ml/kg 95 % confidence limit) Density: 0.88 g/cm³
Any other information on results incl. tables
Original value: 2.4666 ml/kg (1.1765 - 5.1712 ml/kg 95 % confidence limit)
Density: 0.88 g/cm3
Applicant's summary and conclusion
- Conclusions:
- The determined LD50 was 2171 mg/kg bw (rat, female, i.p.).
- Executive summary:
The determined LD50 was 2171 mg/kg bw (rat, female, i.p.).
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