Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 209-810-0
CAS number: 593-81-7
Table 1. Conversion of TMA-HCL (CAS 593 -81
-7) test concentrations to TMA (CAS 75 -50-3) doses.
TMA-HClconc (% in diet)
TMA-HCl (doses, mg/kg bw)
TMA (doses, mg/kg bw)
Rounded to 2 Sig. Fig.
In a 90-day study, male Sprague–Dawley
rats received 0.04. 0.08, 0.16, 0.31, and 0.62 % trimethylamine
hydrochloride in diet (corresponding to 0, 20, 40, 79, 150 and 310 mg/kg
bw of trimethylamine) (Amoore et al., 1978). No mortality was reported,
but decreased weight gain and organ weights was observed in the two
highest dose groups (at 0.31 & 0.62 % in diet). Based
on the study results, NOAEL of 0.16 % diet TMA-HCl (= 130 mg/kg bw/day
TMA-HCl (rounded from 128) = 79 mg/kg bw TMA) was established.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again