Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Exposure related observations in humans: other data

Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Insufficient information to determine reliability

Data source

Reference
Reference Type:
publication
Title:
Urinary Excretion Of Choline Metabolites Following Choline Administration In Normals And Patients With Hepatobiliary Diseases
Author:
De la Huerga, J., and Popper., H.
Year:
1951
Bibliographic source:
J. Clin. Invest. 30(5): 463-470

Materials and methods

GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Trimethylammonium chloride
EC Number:
209-810-0
EC Name:
Trimethylammonium chloride
Cas Number:
593-81-7
Molecular formula:
C3H9N.ClH
IUPAC Name:
N,N-dimethylmethanaminium chloride

Results and discussion

Results:
Rapid elimination in the urine was observed in 2 patients with liver disease after an oral dose of 1.2-2.3 g TMA hydrochloride. No side-effects were observed.

Applicant's summary and conclusion