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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1970
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: This study is classified as reliable with restrictions because it is an acceptable, well-documented publication that closely follows OECD Guideline 401.

Data source

Reference
Reference Type:
publication
Title:
The Toxicological Properties of Hydrocarbon Solvents
Author:
Hine, CH, and Zuidema, HH
Year:
1970
Bibliographic source:
Industrial Medicine, Vol. 39, No. 5, May 1970.

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
no
Test type:
acute toxic class method
Limit test:
yes

Test material

Constituent 1
Reference substance name:
5-80% n-hexane
IUPAC Name:
5-80% n-hexane

Test animals

Species:
rat
Strain:
Long-Evans
Sex:
male
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 150-300 g

Administration / exposure

Route of administration:
oral: gavage
Details on oral exposure:

MAXIMUM DOSE VOLUME APPLIED: 25 ml/kg
Doses:
up to 25 ml/kg
No. of animals per sex per dose:
6 males
Details on study design:
- Duration of observation period following administration: 14 days

Statistics:
Litchfield and Wilcoxen.

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
> 25 mL/kg bw
Remarks on result:
other: 16.75 g/kg
Mortality:
No mortality at doses up to 25 ml/kg (16.75 g/kg (density 0.67)).

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The oral LD50 for rats is > 25 ml/kg.
Executive summary:

This study examined the oral toxicity of commercial hexane. 6 male rats were given doses of up to 25 ml/kg of test substance by oral gavage. The animals were then observed for 14 days for mortality. No mortality was observed at any of the doses. The oral LD50 is therefore > 25 ml/kg (16.75 g/kg; density of 0.67).