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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1956

Materials and methods

GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Tetrachloroethylene
EC Number:
204-825-9
EC Name:
Tetrachloroethylene
Cas Number:
127-18-4
Molecular formula:
C2Cl4
IUPAC Name:
tetrachloroethene

Test animals

Species:
rabbit

Administration / exposure

Type of coverage:
occlusive
Duration of exposure:
24 hours
Doses:
1.3, 2.5, 5, 10 and 20 g/kg bw
No. of animals per sex per dose:
4
Control animals:
not specified
Details on study design:
Brief details are available of a study in which groups of 4 rabbits were exposed for 24 hours to undiluted tetrachloroethylene by dermal application under an occlusive dressing.

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 10 000 mg/kg bw
Mortality:
Mortality data (0/4 at 1.3 g/kg, ¼ at 2.5, 5 and 10 g/kg and 2/4 at 20 g/kg) indicate low toxicity, with the estimated LD50 being greater than 10 g/kg.
Clinical signs:
other: Convulsions occurred in 2-5 minutes at 20 g/kg.
Other findings:
There was necrosis at application sites at all doses.

Applicant's summary and conclusion