Registration Dossier
Registration Dossier
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EC number: 204-825-9 | CAS number: 127-18-4
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP, non-guideline study, acceptable for assessment
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
Materials and methods
- Principles of method if other than guideline:
- Method to investigate the respiratory irritant potential of tetrachloroethylene in male rats.
- GLP compliance:
- yes
- Type of method:
- in vivo
- Endpoint addressed:
- respiratory irritation
Test material
- Reference substance name:
- Tetrachloroethylene
- EC Number:
- 204-825-9
- EC Name:
- Tetrachloroethylene
- Cas Number:
- 127-18-4
- Molecular formula:
- C2Cl4
- IUPAC Name:
- tetrachloroethene
- Details on test material:
- limited information available
Constituent 1
Test animals
- Species:
- rat
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- limited information available
Administration / exposure
- Route of administration:
- inhalation
- Details on exposure:
- limited information available
- Details on analytical verification of doses or concentrations:
- limited information available
- Duration of treatment / exposure:
- 25 minutes
- Frequency of treatment:
- single exposure
- Post exposure period:
- not applicable
Doses / concentrations
- Remarks:
- Doses / Concentrations:10000 ppm (69000 mg/m3)Basis:
- No. of animals per sex per dose:
- no data
- Details on study design:
- not applicable
Examinations
- Examinations:
- limited information available
- Positive control:
- not applicable
Results and discussion
- Details on results:
- Exposures of about 10000 ppm (69000 mg/m3) for 25 minutes do not cause respiratory irritation.
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Conclusions:
- Under the conditions of the study, exposures of about 10000 ppm (69000 mg/m3) for 25 minutes did not cause respiratory irritation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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