Isobutyraldehyde

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Range-finding toxicity data

Author:

Smyth H.F.

Year:

1954

Bibliographic source:

AMA Arch Ind Hyg Occup Med. 1954 Jul;10(1):61-8.

Reference 2

Reference Type:

publication

Title:

Unnamed

Year:

1991

Report date:

1991

Reference 3

Reference Type:

publication

Title:

Industrial hygiene and toxicology, Second Revised Edition, Volume II

Author:

Fassett D.W.

Year:

1962

Bibliographic source:

p. 1966-1978

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Principles of method if other than guideline:

Inhalation of known vapor concentrations by rats is conducted with flowing streams of vapors prepared by various styles of proportioning pumps . Nominal concentrations are recorded and not confirmed by analytical methods. Exposures are four hours long. Concentrations are in an essentially logarithmic series with a factor of two. The concentration yielding fractional mortality among six rats within 14 days was reported. Where no fractional mortality was observed, both the concentration yielding no mortality and that yielding complete mortality are indicated.

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Isobutyraldehyde

EC Number:

201-149-6

EC Name:

Isobutyraldehyde

Cas Number:

78-84-2

Molecular formula:

C4H8O

IUPAC Name:

2-methylpropanal

Details on test material:

- Name of test material: isobutyraldehyde

Test animals

Species:

rat

Strain:

not specified

Sex:

male

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

not specified

Vehicle:

air

Details on inhalation exposure:

Inhalation of know vapor concentrations by rats is conducted with flowing streams of vapors prepared by various styles of proportioning pumps.

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

4 h

Concentrations:

8000 and 16000 ppm

No. of animals per sex per dose:

6

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days

Results and discussion

Effect levels

Sex:

female

Dose descriptor:

LC50

Effect level:

> 23.6 mg/L air

Based on:

test mat.

Exp. duration:

4 h

Remarks on result:

other: 1/6 animals died (8000 ppm)

Mortality:

8000 ppm: Mortality (one animal of six animals) occurred after exposure for 4 hours within 14 days.
16000 ppm: All animals died