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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1969
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Followed appropriate guidelines

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1969
Report date:
1969

Materials and methods

Principles of method if other than guideline:
Data scored according to the method of Draize, Woodard and Calvery (Journal of Pharm. and Exp. Therapeutics, Volume 82, Decemeber, 1944)
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Adiponitrile
EC Number:
203-896-3
EC Name:
Adiponitrile
Cas Number:
111-69-3
Molecular formula:
C6H8N2
IUPAC Name:
hexanedinitrile
Details on test material:
- Name of test material (as cited in study report): Refined Adiponitrile
- Lot/batch No.: 957

Test animals

Species:
rabbit

Test system

Type of coverage:
occlusive
Preparation of test site:
other: clipped
Vehicle:
unchanged (no vehicle)
Controls:
no
Amount / concentration applied:
Undiluted compound was applied
Duration of treatment / exposure:
24 hours
Observation period:
168 hours
Number of animals:
3
Details on study design:
TEST SITE
- Area of exposure: skin
- Type of wrap if used: plastic strips

REMOVAL OF TEST SUBSTANCE
- Time after start of exposure: 24 hours

SCORING SYSTEM: according to the method of Draize, Woodard and Calvery.

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Remarks:
0
Basis:
mean
Remarks:
All animals received a score of zero throughout the observation period
Time point:
24/48/72 h
Score:
0
Max. score:
0
Reversibility:
fully reversible
Remarks on result:
no indication of irritation
Irritation parameter:
edema score
Basis:
mean
Remarks:
all animals received a score of zero
Time point:
24/48/72 h
Score:
0
Max. score:
0
Reversibility:
fully reversible
Remarks on result:
no indication of irritation

Any other information on results incl. tables

 Animal-sex  1 hour  24 hours  48 hours  72 hours  120 hours  168 hours
 1 - male 0 0  0 0 0 0
 2 - female 0 0 0 0 0 0
 3 - male 0 0 0 0 0 0

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: not specified
Conclusions:
The data are scored according to the method of Draize, Woodard and Calvery. The compound was classed as non-irritating when applied to the intact skin of male and female rabbits. No erthema or edema developed when the compound was applied undiluted for twenty-four hours. All animals received a score of zero throughout the observation period.
Executive summary:

The undiluted compound was applied to the clipped, intact skin of albino male and female rabbits and removed after twenty-four hours. the application was covered with plastic strips to retard evaporation and avoid contamination.

Observations were made over a period of several days for irritation.

The data, scored according to the method of Draize, Woodard and Calvery (Journal of Pharm. and Exp. Therapeutics, Volume 82, December, 1944) are shown.

The compound was classed as non-irritating when applied undiluted to intact skin of male and female rabbits.