Adiponitrile

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1969

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Followed appropriate guidelines.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1969

Report date:

1969

Materials and methods

Principles of method if other than guideline:

Oral LD50 according to a modification of the method of E.J. de Beer

GLP compliance:

not specified

Remarks:

Oral LD50 according to a modification of the method of E.J. de Beer

Test type:

other: Oral LD50 according to a modification of the method of E.J. de Beer

Test material

Test material information

Constituent 1

Reference substance name:

Adiponitrile

EC Number:

203-896-3

EC Name:

Adiponitrile

Cas Number:

111-69-3

Molecular formula:

C6H8N2

IUPAC Name:

hexanedinitrile

Details on test material:

- Name of test material (as cited in study report): Refined Adiponitrile
- Lot/batch No.: 957

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Administration / exposure

Route of administration:

oral: unspecified

Vehicle:

corn oil

Doses:

The doses given to the rats were 158 mg/kg, 200 mg/kg, 251 mg/kg and 316 mg/kg.

No. of animals per sex per dose:

Three female and two male were dosed at 158 mg/kg.
Three male and two female were dosed at 200 mg/kg.
Three female and two male were dosed at 251 mg/kg.
Three male and two female were dosed at 316 mg/kg.

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

215 other: mg/kg

Remarks on result:

other: 198-235 mg/kg (lower and upper limits)

Applicant's summary and conclusion

Interpretation of results:

moderately toxic

Remarks:

Migrated information Criteria used for interpretation of results: not specified

Conclusions:

The oral LD 50 for male and female rats was placed at 215 milligrams per kilogram with lower and upper limits of 198 to 235 milligrams per kilogram.

Executive summary:

The oral LD 50 for male and female rats was placed at 215 milligrams per kilogram with lower and upper limits of 198 to 235 milligrams per kilogram. The compound was classed as moderately toxic by oral ingestion in male and female rats. Survival time was several hours to five days with most deaths occuring within two days. Toxic symptons included reduced appetite and activitiy, increasing weakness, and collapse. At autopsy there was liver discoloration, lung hyperemia, gaseous and inflammed intestinal tract, and distended coronaries. Surviving animals were sacrified nine days after dosing. Viscera of the animals on lower test level hyperemia was noted on the upper test levels.