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EC number: 607-759-2
CAS number: 25618-55-7
In this study the test item dissolved in ethanol/water (7:3, v:v) was
assessed for its possible contact allergenic potential.
For this purpose a local lymph node assay was performed using test item
concentrations of 25, 50 and 100 % by topical application to the dorsum
of each ear lobe (left and right) for three consecutive days. A control
group of four mice was treated with the vehicle only.
All treated animals survived the scheduled study period.
No clinical signs were observed in any animals of the control group or
group 2 (25%). About 3 hours after the first topical application, a
slight ear erythema was observed at both dosing sites in all mice of
group 4 (100%, undiluted), persisting for a total of four days. On the
second application day, a slight ear erythema was observed at both
dosing sites in all mice of group 3 (50%), persisting for a total of two
In this study Stimulation Indices (S.I.) of 1.4, 2.1, and 1.9 were
determined with the test item at concentrations of 25, 50, and 100 % in
ethanol/water (7:3, v:v), respectively.
The test item was not a skin sensitiser in this assay.
Based on all available data the registered substance is not a skin
sensitiser and therefore is not subject for classification and labelling
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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