Registration Dossier

Diss Factsheets

Toxicological information

Basic toxicokinetics

Currently viewing:

Administrative data

basic toxicokinetics
Type of information:
other: theoretical approach
Adequacy of study:
key study
Study period:
28 May, 2010
other: not applicable
Rationale for reliability incl. deficiencies:
other: Study is based on expert judgement.

Data source

Reference Type:
study report
Report date:

Materials and methods

Objective of study:
other: toxicokinetic assessment
Principles of method if other than guideline:
A theoretical approach of the toxicokinetic properties of the substance based on the available physico-chemical properties and toxicological data.

Test material

Constituent 1
Reference substance name:
Reference substance 001
Details on test material:
- Name of test material (as cited in study report): Polyglycerol-3
- Substance type: organic liquid
- Physical state: Colourless to pale yellow viscous liquid
- Analytical purity:
27.9% Diglycerol
46.0% Triglycerol
17.9% Tetraglycerol
5.6% Pentaglycerol
2.6% Hexaglycerol and higher
- Purity test date: no data
- Lot/batch No.: RBA081008A
- Expiration date of the lot/batch: 31 May 2010
- Stability under test conditions: stabile

Results and discussion

Preliminary studies:
See below

Applicant's summary and conclusion

Interpretation of results (migrated information): low bioaccumulation potential based on study results
For risk assessment purposes the following absorption factors were derived:
oral absorption factor: 100%
dermal absorption factor: 100%
inhalation absorption factor: 100%