Registration Dossier

Diss Factsheets

Physical & Chemical properties

Water solubility

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
20 December 2008 to 12th February 2009
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study performed to GLP and guideline
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
GLP compliance:
yes
Type of method:
flask method
Water solubility:
0.001 g/L
Temp.:
20 °C
pH:
5.5

Table 1: Results of preliminary test

Sample

Concentration (g/l)

Observations

Solution pH

1

1.5 x 10-3

Excess un-dissolved test material was observed at the base a clear, colourless solution.

7.3

The preliminary estimate of water solubility was less than 1.5 x 10 -3 g/l (as test material)

Table 2: Mean concentration (g/l) of manganese and mean equivalent test material concentration (g/l) in the sample solutions

Sample

Time shaken at ~30°C (hours)

Time shaken at ~20°C (hours)

Manganese concentration (g/l)

Equivalent manganese oxide concentration (g/l)

Solution pH

1

24

24

6.9 x 10-4

9.0 x10-4

5.5

2

48

24

6.5 x 10-4

8.4 x 10-4

5.5

3

72

24

6.3 x 10-4

8.2 x 10-4

5.5

No significant manganese concentration (<0.01 mg/l) was detected in the matrix blank on analysis.

The preliminary water solubility test indicated that the column elution method should have been performed as the solubility was less than 1 x 10-2g/l. However, in the absence of a suitable volatile organic solvent for the coating of inorganic substances onto a suitable support material, this method could not be used. Experience has shown that when the support material is coated by substances present as a suspension in a solvent, as opposed to a true solution, the test material breaks away from the support material over time, migrating into the reservoirs and invalidating the determination.

Conclusions:
Interpretation of results: slightly soluble (0.1-100 mg/L)
The water solubility of the test material has been determined to be 6.6 x 10-4 g/l of manganese in solution at 20.0 ± 0.5°C. This was equivalent to 8.5 x 10-4 g/l of manganese oxide in solution based on the theoretical manganese content of the test material.

Description of key information

The water solubility of the test material has been determined to be 6.6 x 10^-4 g/l of manganese in solution at 20.0 ± 0.5°C. This was equivalent to 8.5 x 10^-4 g/l of manganese oxide in solution based on the theoretical manganese content of the test material.

Key value for chemical safety assessment

Water solubility:
0.85 mg/L
at the temperature of:
20 °C

Additional information

The water solubility of the test material has been determined to be 6.6 x 10 ^-4 g/l of manganese in solution at 20.0 ± 0.5°C. This was equivalent to 8.5 x 10 ^-4 g/l of manganese oxide in solution based on the theoretical manganese content of the test material.

Categories Display