Dimethyl sulphate

Guidance on Safe Use

First-aid measures

4.1 General informations

Move victim out of danger zone. Position and transport victim on their side. In case of

respiratory distress, bring into semi-upright, seated position. Remove contaminated

clothing immediatley and dispose off safely. Put victim at rest, cover with a blanket

and keep warm. Do not leave victim unattended. In case of accident or if you feel

unwell, seek medical advice immediately (show safety data sheet if possible).

Symptoms of poisoning may develop several hours following exposure. Victim should

be under medical observation for at least 48 hours after exposure.

Medical advice absolutely requred!

4.2 In case of inhalation

Provide fresh air. In case of breathing difficulties administer oxygen. No mouth-tomouth

or mouth-to-nose resuscitation.Use respiratory bag or oxygen resuscitation

apparatus. When inhaling vapours, first symptoms of poisoning may develop hours

later, so always consult a doctor.

4.3 In case of skin contact

Remove contaminated clothing immediatley and dispose off safely. After contact with

skin, wash immediately with: Water. Subsequently wash again with: Ammonia (3 %).

Symptoms of poisoning may develop several hours following exposure. Victim should

be under medical observation for at least 48 hours after exposure.

4.4 In case of eye contact

In case of contact with eyes, rinse immediately with plenty of flowing water for 10 to

15 minutes holding eyelids apart. Subsequently wash again with: soda solution,

diluted. Subsequently consult an ophthalmologist.

4.5 In case of ingestion

Rinse mouth immediately and drink large quantities of water. Have victim drink large

quantities of water, with active charcoal if possible. Do not induce vomiting.

4.6 Self-protection of the first aider

First aid assistant: Pay attention to self-protection! No mouth-to-mouth or mouth-tonose

resuscitation.Use respiratory bag or oxygen resuscitation apparatus.

4.7 Information to physician

4.7.1 Routes of exposure

The substance can be absorbed into the body by inhalation of its vapour, through the

skin and by ingestion.

4.7.2 Hazards

Effects of short-term exposure:

The substance is corrosive to the eyes, the skin, the

respiratory tract. Corrosive on ingestion. Inhalation of the

vapour may cause lung oedema (see Notes). Ingestion of the

substance may cause oedema of lips, tongue and pharynx.

The substance may cause effects on the liver, kidneys and

central nervous system, resulting in impaired functions.

Exposure above the OEL may result in death. The effects

may be delayed. Medical observation is indicated.

Effects of long-term or repeated

exposure:

Lungs may be affected by repeated or prolonged exposure to

the vapour. This substance is probably carcinogenic to

humans.

Notes:

The onset of symptoms can occur after a relatively

asymptomatic latent period of 6-24 hours. Commercial

dimethyl sulfate may contain trace amounts of sulfuric acid.

Depending on the degree of exposure, periodic medical

examination is suggested. The symptoms of lung oedema

often do not become manifest until a few hours have passed

and they are aggravated by physical effort. Rest and medical

observation are therefore essential. Immediate administration

of an appropriate inhalation therapy by a doctor or a person

authorized by him/her, should be considered. No odour

warning if toxic concentrations are present. Do NOT take

working clothes home. NEVER pour water into this

substance; when dissolving or diluting always add it slowly to

the water.

4.7.3 Symptoms

In case of inhalation:

Burning sensation. Cough. Headache. Shortness of breath.

Sore throat. Symptoms may be delayed

In case of skin contact: MAY BE ABSORBED! Skin burns. Pain. Blisters.

In case of eye contact: Redness. Pain. Blurred vision. Severe deep burns.

In case of ingestion:

Abdominal cramps. Burning sensation. Convulsions.

Diarrhoea. Shock or collapse. Vomiting. (Further see

Inhalation).

4.7.4 Treatment

First Aid, decontamination, treatment of symptoms.

Fire-fighting measures

5.1 Suitable extinguishing media

Foam. Extinguishing powder.

5.2 Extinguishing media which must not be used for safety reasons

Water.

5.3 Special exposure hazards arising from the substance or preparation itself,

combustion products, resulting gases

In case of fire may be liberated:

Carbon monoxide. Carbon dioxide (CO2). Sulphur dioxide (SO2). Sulphur trioxide.

5.4 Special protective equipment for fire-fighters

Wear a self-contained breathing apparatus and chemical protective clothing. In case

of fire: use acidproof devices.

5.5 Additional information

Intervention Actions-General

PUBLIC SAFETY HAZARD - Warn people nearby to stay indoors with doors and

windows closed. Stop any ventilation. Consider evacuation of people in immediate

danger. Keep upwind. Put on protective equipment before entering danger area.

Minimise number of personnel in risk area. Warn people to leave and not to re-enter

basements, sewers or other confined spaces. Keep upwind. Put on protective

equipment before entering danger area.

Intervention Actions-Fire (involving the substance)

Heating of container(s) will cause pressure rise with risk of bursting and subsequent

explosion. Gives off toxic and irritant fumes when heated or burning. May attack

metals and produce hydrogen gas which may form explosive mixture with air. The

vapour may be invisible and is heavier than air. It spreads along the ground and may

enter sewers and basements. Keep container(s) cool with water. Extinguish with

water fog (spray). Do not use water jet to extinguish. Use water spray to knock down

fire fumes if possible. Avoid unnecessary run-off of extinguishing media which may

cause pollution.

ERI-Card

6-57 - HIGHLY TOXIC CORROSIVE LIQUID

Accidental release measures

6.1 Personal precautions (spillage)

Wear personal protection equipment.

6.2 Environmental precautions

Stop leaks if possible. Contain spillage by any means available.

Cover drains. Do not allow to enter into soil/subsoil. Do not empty into drains or the

aquatic environment.

6.3 Methods for cleaning up

Refer to chapter 6.4

6.4 Additional information

Evacuate danger area! Consult an expert! Ventilation. Collect leaking and spilled

liquid in sealable containers as far as possible. Absorb remaining liquid in dry sand or

inert absorbent and remove to safe place. Do NOT wash away into sewer. Personal

protection: complete protective clothing including self-contained breathing apparatus.

Handling and storage

7.1 Handling

7.1.1 Advices on safe handling

Protective measures

Wear personal protection equipment. Refer to chapter 8. Do not eat, drink, smoke or

sneeze at the workplace.

Dangerous areas must be delimited and marked with appropriate warning and safety

signs. In the immediate working surroundings there must be: Emergency spray

installed. provide eye wash and label its location conspicuously. provide sufficient

washing facilities. Fill only into labelled container. Instruction on the hazards and the

protective measures using instruction manual are required with signature.

Working areas must be arranged in such a manner that they can be cleaned at all

times.

7.1.2 Technical measures

Measures to prevent aerosol and dust generation

All work processes must always be designed so that the following is excluded:

Inhalation. Skin contact. Eye contact. Transfer and handle product only in closed

systems.

Measures required to protect the environment

Cover drains. Do not allow to enter into soil/subsoil. Do not empty into drains or the

aquatic environment.

7.1.3 Specific requirements or handling rules

The floor should be leak tight, jointless and not absorbent. Do not transport with/using

compressed air

7.1.4 Precautions against fire and explosion

Usual measures for fire prevention. Inspect the electrical fittings regularly against the

higher risk of corrosion. Welding only under supervision. Work that requires fire or

heat may only be carried out with written permission (e.g. fire permit).

7.2 Storage

7.2.1 Technical measures and storage conditions

Keep in locked storage or only make accessible to specialists or their authorised

assistants. Keep container tightly closed. Keep/Store only in original container. Place

fragile vessels in break-proof outer vessels. Protect against: Humidity. UVradiation/

sunlight.

7.2.2 Hints on storage assembly

Keep away from food, drink and animal feedingstuffs.

7.2.3 Further information on storage conditions

Storage class 6.1 A brennbare giftige Stoffe

Storage temperature 10 °C – 30 °C

Relative air humidity -

Maximum period of storage 2 Jahre / years / Años / ans / anni / jaren

Transport information

Land transport (UN RTDG/ADR/RID)

UN number:

1595

Shipping information

Proper shipping name and description:

DIMETHYL SULPHATE

Chemical name:

DIMETHYL SULPHATE

Language:

English

Labels:

T+

SpecialProvisions

Inland waterway transport (UN RTDG/ADN(R))

UN number:

not applicable

Shipping

Remarks

Marine transport (UN RTDG/IMDG)

UN number:

not applicable

Shipping

Remarks

Air transport (UN RTDG/ICAO/IATA)

UN number:

not applicable

Shipping

Remarks

Additional transport information

Additional information

Special provisions / remarks / other:

ADR label: 6.1 + 8

Exposure controls / personal protection

Respiratory protection: Respiratory protection required in case of: exceeding critical value Suitable respiratory protective equipment: Combination filtering device (DIN EN 141). Type of mask: Full-face mask (DIN EN 136). Filtering device: A-P3

Hand protection: Use protective gloves. The glove material must be sufficiently impermeable and resistant to the substance. Check the tightness before wear. Gloves should be well cleaned before being removed, then stored in a well ventilated location. Pay attention to skin care. Textile or leather gloves are completely unsuitable. The following information is valid for aqueous, saturated solutions of the substance. Suitable materials for gloves are (brakthrough time>=8 hours) CR (polychloroprenes, Chloroprene rubber) - CR (0,5 mm); Butyl rubber - Butyl (0,5 mm); The times listed are suggested by measurements taken at 22 degree C and constant contact. Temperatures raised by warmed substances, body heat, etc. and a weakening of the effective layer thickness caused by expansion can lead to a significantly shorter breakthrough time. In case of doubt contact the gloves' manufacturer. A 1.5-times increase / decrease in the layer thickness doubles / halves the breakthrough time. This data only applies to the pure substance. Transferred to mixtures of substances, these figures should only be taken as an aid to orientation.

Eye protection: Suitable eye protection: Tightly sealed safety glasses.

Protective clothing: Suitable protection of the body: Chemical resistant safety shoes. Protective clothing: DIN EN 13034

General health and safety measures: When using do not eat, drink, smoke, sneeze. Wash hands and face before breaks and after work and take a shower if necessary. Draw up skin protection programme. Used working clothes must not be worn outside the working area. Separate storage of work clothes. Immediately remove any contaminated clothing, shoes or stockings. In the immediate working surroundings there must be: Emergency shower installed. Make available sufficient washing facilities. Provide eye shower and label its location conspicuously. Set out skin protection guidelines. Only wear fitting, comfortable and clean protective clothing.

Environmental exposure controls:

See “handling and storage”. No additional measures necessary.

Stability and reactivity

Conditions to avoid: In case of warming: Danger of bursting container. Thermal decomposition can lead to the escape of irritating gases and vapours. Above 83/C explosive vapour/air mixtures may be formed.

Materials to avoid:  The vapour is heavier than air. The substance decomposes on heating or on burning producing toxic fumes including sulfur oxides. The solution in water is a medium strong acid. Reacts with water to produce sulfuric acid with evolution of heat. Reacts violently with concentrated aqueous ammonia, bases, acids and strong oxidants with risk of fire and explosion.

Hazardous decomposition products: Sulphur oxides. Carbon monoxide. Carbon dioxide. Methanol. Gas / vapours, irritant and toxic.

Disposal considerations

Collect the waste separately. Waste disposal according to EC-regulations 75/442/EEC and 91/689/EEC in the corresponding versions, covering waste and dangerous waste. Dispose of waste according to applicable local, state, and federal regulations. List of proposed waste codes/waste designations in accordance with EWC. The allocation of waste identity numbers/waste descriptions must be carried out according to the EEC, specific to the industry and process.