Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 260-350-7 | CAS number: 56706-10-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
The key skin sensitisation study is a reliable adjuvant study conducted
according to OECD 406 on a closely related material. The study
identified a sensitization index of 5% (EU criteria for sensitization by
skin contact would require a positive response in at least 30% of the
test group).
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
The key study for sensitisation was read across from the related substance polysulfides, bis[3-(triethoxysilyl)propyl] (CAS 211519-85-6), conducted according to an appropriate OECD test guideline, and in compliance with GLP, and found the test material not sensitising (WIL 2000).
The sensitization index was reported to be 5%. EU criteria for sensitization by skin contact would require a positive response in at least 30% of the test group. The test substance contained a mixture of the registered substance and the related S3 and S4 isomers, but the relative proportions of each are not known.
The registered substance contains S2 as the main constituent, with S3 present as an impurity.The substance in the study used for read across, Polysulfides (CAS 211519 -85 -6), contained up to 25% of the registered substance. The other constituents are the structurally similar analogue substances S3 and S4. Due to the structural similarity and similar physicochemical properties, the read-across substance is considered to be representative of the registered substance, as the Polysulfides gave a clear negative result and there is no reason to expect a positive result from a higher proportion of S2 constituent. See discussion in the reproductive toxicity section endpoint summary (Section 7.8, section 5.9 for the CSR) for a more detailed justification for the read-across approach.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Based on the available data, 4,4,13,13-tetraethoxy-3,14-dioxa-8,9-dithia-4,13-disilahexadecane does not require classification for sensitisation according to Regulation (EC) 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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