Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 260-350-7 | CAS number: 56706-10-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
EL50 (72 h): > 500 mg/l (nominal) and EL10 (72 h): 280 mg/l (nominal) based on: growth rate in Scenedesmus subspicatus (new name: Desmodesmus subspicatus) in the presence of an ethanol carrier.
This result is supported by: EL50 (96 h) >1000 mg/l (nominal) and EL10 (96 h): >1000 mg/l (nominal) based on: biomass and yield in Scenedesmus subspicatus (new name: Desmodesmus subspicatus), in media prepared by direct addition, and an EL50 of 700 mg/l (nominal) based on: yield in Scenedesmus subspicatus (new name: Desmodesmus subspicatus), in media prepared by water accommodated fraction (it is likely that the organisms would have been exposed to a mixture of the monomeric silanol hydrolysis product and siloxane oligomers; the effects seen are attributed to precipitated oligomeric or cross-linked by-products; however the results are conservatively interpreted as representative of the parent substance loading because of the need to define an indicative PNEC and assess risk).
Key value for chemical safety assessment
Additional information
A 72-h EL50 value of >500 mg/l and a NOELR of 32 mg/l have been determined for the effects of the test substance on growth rate of Scenedesmus subspicatus in the presence of ethanol as a vehicle. The EL50 and NOELR values significantly exceed the solubility of the substance (approximately 0.01 mg/l) and should therefore be taken to indicate that the test substance is unlikely to be toxic at its solubility limit. Effects on biomass at concentrations ≥64 mg/l may be attributable to the presence of undissolved test material or precipitated by-products.
A 96-h EL50 value of >1000 mg/l (nominal) and EL10 of >1000 mg/l (nominal) have been determined for the effects of polysulfides, bis[3-triethoxysilylpropyl] (CAS 211519-85-6) on yield of Scenedesmus subspicatus as determined by fluorescence measurement. This test was conducted in media prepared by direct addition. Based on the static exposure regime, it is likely that the organisms would have been exposed to a mixture of the dissolved and undissolved parent substance, monomeric silanol hydrolysis product and siloxane oligomers. Insoluble oligomers may have precipitated out of solution to an extent in the course of the test. The test results have been interpreted in this context. No analytical verification was performed. In view of the media preparation method and duration of study, the effects seen are attributed to a mixture of parent, silanol hydrolysis product and oligomeric or cross-linked by-products. Physical effects could have contributed.
A 96-h EL50 value of 700 mg/L and a 96-h EL10 of 60 mg/L have been determined for the effects of polysulfides, bis[3-triethoxysilylpropyl] (CAS 211519-85-6) on yield of Scenedesmus subspicatus as determined by fluorescence measurement. A NOELR of 1000 mg/l has been estimated from the test results by the report authors but does not seem realistic given the EL50 and EL10 values. The results are above the expected water solubility of the test substance (approximately 0.01 mg/L). There was evidence of undissolved test material (turbidity) in the water-accommodated fractions and this may have contributed to effects observed at the high test substance loading rates utilised in the test. Based on the test media preparation methods and exposure regime, it is likely that the organisms would have been exposed to a mixture of the monomeric silanol hydrolysis product and siloxane oligomers. Insoluble oligomers may have precipitated out of solution to an extent during the media preparation and in the course of the test. The test results have been interpreted in this context. This is reflected in the observation of turbidity in test media, although no analytical verification was performed. In view of the media preparation method and duration of study, the effects seen are attributed to precipitated oligomeric or cross-linked by-products. Physical effects are likely to have dominated any intrinsic toxic effects.
The only quantified NOECs and EL10 values are considerably higher than the limit of solubility. The registration substance itself appears to be non-toxic to algae at the solubility limit. Given the half-life of the hydrolysis reaction at pH7 and 25˚C, the chemical safety assessment focusses on the parent form.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

EU Privacy Disclaimer
This website uses cookies to ensure you get the best experience on our websites.