Methane

Long-term toxicity to aquatic invertebrates

Administrative data

Endpoint:

long-term toxicity to aquatic invertebrates

Type of information:

(Q)SAR

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: QSAR calculation, reliable with restrictions

Justification for type of information:

QSAR prediction: migrated from IUCLID 5.6

Data source

Reference

Reference Type:

other: Computer model

Title:

ECOWIN v1 ECOSAR Classes for Microsoft Windows

Author:

Nabholz V and Mayo-Bean K

Year:

2009

Bibliographic source:

USEPA OPPT Risk Assessment Division

Materials and methods

Principles of method if other than guideline:

The Ecosar class program has been developed primarily for the evaluation of neutral organic compounds and organic classes with excess toxicity. The QSARs in the Ecosar program are developed for chemical classes based on measured test data that have been submitted by industry or they are developed by other sources for chemicals with similar structures, e.g., phenols. Using the measured aquatic toxicity values and estimated Kow values, regression equations can be developed for a class of chemicals. Toxicity values for new chemicals may then be calculated by inserting the Kow into the regression equation and correcting the resultant value for the molecular weight of the compound.

GLP compliance:

no

Remarks:

Not applicable

Test material

Test material information

Constituent 1

Reference substance name:

Reference substance 003

Cas Number:

74-82-8

Molecular formula:

C H4

Details on test material:

Not applicable

Specific details on test material used for the study:

Details on properties of test surrogate or analogue material (migrated information):
Not applicable

Sampling and analysis

Details on sampling:

Not applicable

Test solutions

Details on test solutions:

Not applicable

Test organisms

Test organisms (species):

Daphnia sp.

Details on test organisms:

Not applicable

Study design

Test type:

other: Not applicable

Water media type:

freshwater

Post exposure observation period:

Not applicable

Test conditions

Hardness:

Not applicable

Test temperature:

Not applicable

pH:

Not applicable

Dissolved oxygen:

Not applicable

Salinity:

Not applicable

Nominal and measured concentrations:

Not applicable

Details on test conditions:

Not applicable

Results and discussion

Effect concentrations

Duration:

30 d

Dose descriptor:

other: ChV

Effect conc.:

3.886 mg/L

Nominal / measured:

estimated

Conc. based on:

test mat.

Details on results:

calculated using the neutral organic QSAR. Log kow entered (1.09) and melting point entered (-182.47°C)

Results with reference substance (positive control):

Not applicable

Reported statistics and error estimates:

Not applicable

Applicant's summary and conclusion

Validity criteria fulfilled:

not applicable

Remarks:

QSAR

Conclusions:

The calculated 30 day ChV for methane was 3.886mg/l

Executive summary:

The calculated 30 day ChV for methane was 3.886mg/l. Measured data are not available for methane for this endpoint. Due to the practical difficulties associated with the ecotoxicity testing of gases (i.e. maintaining exposure concentrations) the use of QSAR toxicity estimates is an appropriate alternative. The ECOSAR model is a reliable and appropriate QSAR model to apply to methane as it is based on a related chemical dataset that calculates the toxicity of neutral organic hydrocarbons whose mode of action is non-polar narcosis. The endpoint calculated here is therefore a reasonable estimate of its baseline toxicity.