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Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Toxicity and carcinogenicity of potassium bromate--a new renal carcinogen.
Author:
Kurokawa Y; Maekawa A; Takahashi M; et al.
Year:
1990
Bibliographic source:
Environ Health Perspect 87:309-335, 1990. Cited in WHO 2005.
Reference Type:
other: secondary literature
Title:
Sodium bromate
Author:
HSDB
Year:
2019
Bibliographic source:
http://toxnet.nlm.nih.gov/

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 471 (Bacterial Reverse Mutation Assay)
GLP compliance:
not specified
Type of assay:
bacterial reverse mutation assay

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium bromate
EC Number:
232-160-4
EC Name:
Sodium bromate
Cas Number:
7789-38-0
Molecular formula:
BrHO3.Na
IUPAC Name:
sodium bromate

Method

Species / strainopen allclose all
Species / strain / cell type:
S. typhimurium TA 97
Species / strain / cell type:
S. typhimurium TA 98
Species / strain / cell type:
S. typhimurium TA 100
Species / strain / cell type:
S. typhimurium TA 102
Metabolic activation:
not specified

Results and discussion

Additional information on results:
The mutagenic effects of sodium bromate (NaBrO3) and silver bromate (AgBrO3) were evaluated by Kurokawa et al (1990) in microbial tests with Salmonella typhimurium strains TA 97, 98, 100 and 102 to determine the general mutagenic potential of bromate compounds (BrOi3). The authors stated that NaBrO3 and AgBrO3 were negative in all strains tested at maximum concentrations of 5 mg/plate and 25 µg/plate, respectively, without providing further details on the results or the method used.
Remarks on result:
other: unpublished data

Applicant's summary and conclusion

Conclusions:
Under the information reported by Kurokawa et al. (1990), sodium bromate is negative in a microbial tests conducted with Salmonella typhimurium strains TA 97, 98, 100 and 102.
Executive summary:

The mutagenic effects of sodium bromate (NaBrO3) and silver bromate (AgBrO3) were evaluated by Kurokawa et al. (1990) in microbial tests conducted with Salmonella typhimurium strains TA 97, 98, 100 and 102 to determine the general mutagenic potential of bromate compounds (BrO3). The authors stated, that NaBrO3 and AgBrO3 were negative in all strains tested at maximum concentrations of 5 mg/plate and 25 µg/plate, respectively, without providing further details on the results.