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Administrative data

Endpoint:
basic toxicokinetics
Type of information:
other: review
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Review by a recognised source.

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
2001

Materials and methods

Principles of method if other than guideline:
Review of data. Some investigations were performed with potassium bromate. A read across to sodium bromate is justified as both substances dissociated in water.

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium bromate
EC Number:
232-160-4
EC Name:
Sodium bromate
Cas Number:
7789-38-0
Molecular formula:
BrHO3.Na
IUPAC Name:
sodium bromate
Details on test material:
Some investigations were performed with potassium bromate. A read across to sodium bromate is justified as both substances dissociated in water.

Results and discussion

Main ADME resultsopen allclose all
Type:
absorption
Results:
Bromate appears to be rapidly absorbed from the gastrointestinal tract, at least in part unchanged, following oral administration.
Type:
distribution
Results:
Studies in rats indicate that bromate appears in plasma and urine rapidly following ingestion. Oral gavage administration of 100 mg KBrO3/kg to rats resulted in a peak plasma concentration 15 minutes after dosing and a peak urine concentration 1 hour p.a
Type:
metabolism
Results:
Bromate is reduced to bromide in body tissues.
Type:
excretion
Results:
Bromate is excreted mainly in the urine, partly as bromate and partly as bromide. Some bromate may also be eliminated in the feces.
Type:
other: bioaccumulation
Results:
Small amounts of bromine (1–2 ppm) were detected in the adipose tissue of mice, but not of rats, fed bread treated with potassium bromate in a lifetime study.

Metabolite characterisation studies

Metabolites identified:
yes
Details on metabolites:
Bromide.

Applicant's summary and conclusion

Conclusions:
Bromate is rapidly absorbed from the gastrointestinal tract, at least in part unchanged.
It is distributed throughout the body appearing in plasma and urine unchanged and in other tissues as bromide.
Bromate is reduced to bromide in several body tissues, probably by GSH or other sulfhydryl-containing compounds.
Most bromate is excreted in the urine, either as bromate or bromide, but some may leave the body in the feces.
Bromine has been detected in adipose tissue of mice following long-term treatment with bromate.
Executive summary:

Bromate is rapidly absorbed from the gastrointestinal tract, at least in part unchanged.

It is distributed throughout the body appearing in plasma and urine unchanged and in other tissues as bromide.

Bromate is reduced to bromide in several body tissues, probably by GSH or other sulfhydryl-containing compounds.

Most bromate is excreted in the urine, either as bromate or bromide, but some may leave the body in the feces.

Bromine has been detected in adipose tissue of mice following long-term treatment with bromate.