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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1979
Report date:
1979

Materials and methods

Principles of method if other than guideline:
Rats (3/sex/dose) were exposed dermally to the test substance for 24 hours under occlusive conditions. The animals were observed for 14 days and the LD50 was calculated.
GLP compliance:
no
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium methanolate
EC Number:
204-699-5
EC Name:
Sodium methanolate
Cas Number:
124-41-4
Molecular formula:
CH4O.Na
IUPAC Name:
sodium methanolate

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Hagemann, Extertal
- Weight at study initiation: mean males: 220 g, mean females: 190 g
- Diet: ad libitum
- Water: ad libitum

Administration / exposure

Type of coverage:
occlusive
Vehicle:
water
Details on dermal exposure:
TEST SITE
- Area of exposure: backs and flanks of the animals
- % coverage: 50 cm²
- Type of wrap if used: occlusive, impermeable


REMOVAL OF TEST SUBSTANCE
- Washing (if done): with warm water oder warm water/lutrol
- Time after start of exposure: 24 hours


TEST MATERIAL
- Amount(s) applied (volume or weight with unit): not reported
- Concentration (if solution): 50%
- Constant volume or concentration used: not reported
Duration of exposure:
24 hours
Doses:
1000, 2000 mg/kg
No. of animals per sex per dose:
3
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: not specified
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, gross pathology

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
no deaths occured
Clinical signs:
other: Irregular breathing and bad general condition Skin: necrosis after the 24 hour application
Gross pathology:
No macroscopic organ changes apart from skin necrosis were observed.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The acute dermal median lethal dose (LD50) in all animals was determined to be > 2000 mg/kg bodyweight. Skin necrosis was observed after the 24-h exposure.