Registration Dossier
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Diss Factsheets
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EC number: 200-836-8 | CAS number: 75-07-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Additional information
Data concerning the reproductive effects of in vivo administration of acetaldehyde (conducted using physiologically relevant routes of exposure) are limited to the results of one subchronic investigation in which an assessment of ovary weights, testicular weights and other testicular parameters was conducted in hamsters exposed by inhalation. Based on the results of this study, reduced gonad weights have been observed at 1340 ppm (2412 mg/m3) acetaldehyde and higher (Kruysse et al., 1975). [cited from Canadian Environmental Protection Act 1999, Priority substance list assessmnet report on Acetaldehyde]
Effects on developmental toxicity
Additional information
Literature data
Most research on the developmental toxicity of Acetaldehyde was done because of the fact that Acetaldehyde is a direct metabolite of ethanol, and ethanol caused at high doses developmental effects. To receive a similar bioavailabilty of Acetaldehyde as in the case of direct ethanol exposure experimental data was aquired mainly after intraperitoneal injection. Since this is not an appropriate route of exposure to acetaldehyde and the application itself can cause secondary developmental effects the reported data could not be used for the evaluation of the hazard. The only report available in literature that examined the developmental effects of acetaldehyde after oral exposure is only available as meeting abstract with no detailed data. For details see endpoint record.
Developmetal screening study
A non-GLP study similar to OECD guideline 414 examined the teratogenic potential of acetaldehyde in 22 rats after oral admistration of 400 mg/kg bw/d from day 6 through 15 of gestation. The dose selection was based on a maternal tolerance study. It did not induce any maternal or developmental toxic effect under the reported conditions. The NOAEL derived from this study is greater than 400 mg/kg bw/d. (David et al, 1983)
Conclusion
Based on the available data and its reliabilty there is no evidence that acetaldehyde has developmental effects after oral exposure at maternally non-toxic levels. The corresponding NOAEL for developmetal effects after repeated oral exposure is accordingly greater than 400 mg/kg bw/d .
No data is available on developmental effects after inhaltive exposure.
Literature:
David G., Serota, Ph.D. (Hazelton laboratories, USA by order of thr Celanese Corporation), Teratology screen in Rats 1983, Report # 299-534, owner: Celanese Corporation
Justification for classification or non-classification
see above
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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