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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
other: hazard assessment report
Adequacy of study:
supporting study
Study period:
-1995
Reliability:
other: reliable hazard assessment
Rationale for reliability incl. deficiencies:
other: International hazard assessment

Data source

Reference
Reference Type:
other: hazard assessment
Title:
Acetaldehyde
Author:
WHO- International Programm on Chemical Safety
Year:
1995
Bibliographic source:
Environmental Health criteria 167

Materials and methods

Principles of method if other than guideline:
no data available
GLP compliance:
not specified
Test type:
other: different methods

Test material

Constituent 1
Chemical structure
Reference substance name:
Acetaldehyde
EC Number:
200-836-8
EC Name:
Acetaldehyde
Cas Number:
75-07-0
Molecular formula:
C2H4O
IUPAC Name:
acetaldehyde

Test animals

Species:
other: rats, mice and dogs

Results and discussion

Any other information on results incl. tables

Table 1. LD50 values for Acetaldehyde after oral exposure

Rat

oral

1930 mg/kg bodyweight

Smyth et al. (1951)

Rat

oral

660 mg/kg bodyweight

Sprince et al. (1974)

Mouse

oral

1230 mg/kg bodyweight

US NRC (1977)

Dog

oral

> 600 mg/kg bodyweight

Booze&Oehme(1986)

 

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Oral LD50s for acetaldehyde in rats and mice ranged from 660 to 1930 mg/kg body weight.
Executive summary:

The lowest observed LD50 in the rat was 660 mg/kg bw. According to this value Acetaldehyde is harmful if swallowed.