Registration Dossier
Registration Dossier
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EC number: 200-836-8 | CAS number: 75-07-0
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
Acetaldehyde was investigated for inhaltion toxicity in an experimental study that was similar to OECD Guideline 403. From the observed mortalities the LC 50 was determined to be 24.04 mg/L (13300 ppm). Acetaldehyde could thus be considered as of low toxicity when inhaled. Classification accoring to (EC) No 1272/2008 is not indicated.
The oral LD50 in the rat ranges from 660 to 1930 mg/kg bw accoriding to an overview of the WHO-ICPS from 1995. According to this value Acetaldehyde is harmful if swallowed. Nevertheless, the observations from the more relevant inhalatory route indicate that the systemic toxicity of acetaldehyde low and that effects other than systemic effects might have contributed to the lethality after oral exposure of rats. It is reasonable to follow the current EU legal classsification that does not classify acetaldehyde as acute toxic after oral exposure.
Data for the dermal route is not available. Additionally, the dermal route is of minor importance due to the high volatiliy of acetaldehyde at room temperature.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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