Registration Dossier
Registration Dossier
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EC number: 201-327-3 | CAS number: 81-13-0
Endpoint summary
Administrative data
Description of key information
Additional information
Aquatic toxicity
Short-term toxicity to fish
In the key study the acute toxicity of D-Panthenol for fish was estimated by continuous exposure of rainbow trouts for 96 hours, according to the GLP Standard Operation Procedure PSU FT1991. Following an acclimation and adaptation period, groups of ten trouts were exposed under controlled conditions, using a static test system, to three different concentrations of the test compound. As a control, a group of ten fish was exposed to normal city water. Fish were observed daily and behavior and mortality were recorded. Based on the 96-hour acute toxicity study, the NOEC (no observed effect concentration) of D-Panthenol for rainbow trouts (Salmo gairdneri) is > 1000 mg/l.
In a supporting study the short term toxicity to fish was assessed in a study performed in golden orfe equivalent or similar to OECD Guideline 203. Based on the results obtained from testing the EC50 (96 h) was determined to be > 10000 mg/L.
Short-term toxicity to aquatic invertebrates
The short term toxicity of the substance to aquatic invertebrates was tested in daphnia magna in a study performed according to OECD Guideline 202, Part I, 1984. Based on the results obtained from testing the EC50 (48 h) was determined to be > 100 mg/L. No mortalities or any other effects which could be related to the test item. Thus, the substance was considered to be practically non toxic to aquatic invertebrates.
Toxicity to aquatic algae and cyanobacteria
The short term toxicity of the substance to aquatic algae and cyanobacteria was tested in Scenedesmus subspicatus (new name: Desmodesmus subspicatus) in a study performed according to OECD Guideline 201, 1984. Based on the results obtained from testing the EC50 (72 h) was determined to be > 100 mg/L. No mortalities or any other effects which could be related to the test item were noted during the course of the study. Thus, the substance was considered to be practically non toxic to aquatic algae and cyanobacteria.
Toxicity to microorganisms
The toxicity to microorganisms was assessed in a study performed in Pseudomonas putida acoording to DIN 38412, part 8. Based on the results obtained from testing the EC50 (17 h) was determined to be > 10000 mg/L.
In a supporting study performed according to ISO 8192 (Test for Inhibition of Oxygen Consumption by Activated Sludge), the EC20 (30 min) was determined to be > 800 mg/L.
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