Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 219-372-2 | CAS number: 2425-85-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Unknow purity
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
Test material
- Reference substance name:
- 1-(4-methyl-2-nitrophenylazo)-2-naphthol
- EC Number:
- 219-372-2
- EC Name:
- 1-(4-methyl-2-nitrophenylazo)-2-naphthol
- Cas Number:
- 2425-85-6
- Molecular formula:
- C17H13N3O3
- IUPAC Name:
- 1-(4-methyl-2-nitrophenylazo)-2-naphthol
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- 12.5% suspension in sesame oil
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- vegetable oil
- Remarks:
- sesame oil
- Doses:
- 2 times 5000 mg/kg bw were dosed to each rat via gavage within 1 hour
- No. of animals per sex per dose:
- 10
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 10 000 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- LD50 > 10,000 mg/kg
- Executive summary:
No rats died during the study. Passivity and diarrhea were observed after the dosing. Faeces and urine were stained red. The discoloration of the feces was observed up to 7 days after application. The occurrence of reddish skin discoloration after 24 hours was occasionally observed up to the end of study.
The behavior and body weight development were normal in the 14-day follow-up period.
The sections of the killed animals after the experiments were macroscopically inconspicuous
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
