Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 212-081-1 | CAS number: 760-67-8
Endpoint summary
Administrative data
Description of key information
Nonanyl chloride is sensitizing in a valid pre-guideline LLNA.
The same result is expected for 2-ethylhexanoyl chloride due to close structural similarity.
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Additional information:
No data for skin sensitisation for 2-ethylhexynoyl chloride are available, but for the structural analog nonanoyl chloride (CAS: 764-85-2).
In a pre-guideline LLNA with nonanoylchlorid, groups of mice are exposed daily, for 3 consecutive days, to various concentrations of the test chemical or to the relevant vehicle alone, on the dorsum of both ears. On day 5 following the initiation of exposure, mice are injected intravenously with [3H]thymidine and activity measured as a function of isotope incorporation in draining auricular lymph nodes (Kimber and Basketter, 1992). A stimulation index ≥ 3, together was observed in all concentration. Therfore nonanoylchlorid is regarded as sensitizing in the LLNA.
Due to the close sturctural similarity the same result is expected for 2 -ethylhexanoyl chloride.
Respiratory sensitisation
Endpoint conclusion
- Additional information:
As the substance is toxic by inhalation no additional respiratory sensitization classification is warranted
Justification for classification or non-classification
Nonanoyl chloride is sensitizing in a valid pre-guideline LLNA, the same result is expected for 2-ethylhexanoyl chloride due to close structural similarity. As the substance is toxic by inhalation no additional respiratory sensitization classification is warranted.
According to the study results the substance is classified as skin sensitising cat 1 (H317) accronding of regulations 1272/2008/EC.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
