Registration Dossier
Registration Dossier
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EC number: 201-116-6 | CAS number: 78-42-2
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- No OECD guideline or GLP defined, no analytical tests performed.
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicological Studies on Tri-(2-Ethylhexyl)-Phosphate
- Author:
- MacFarland H.N.; Punte C.L.
- Year:
- 1 966
- Bibliographic source:
- Archives of Environmental Health Vol. 13, pp.13-20
Materials and methods
- Principles of method if other than guideline:
- other: Acute Toxicity, inhalation in rats
- GLP compliance:
- no
- Test type:
- other: Acute Toxicity, inhalation in rats
Test material
- Reference substance name:
- Tris(2-ethylhexyl) phosphate
- EC Number:
- 201-116-6
- EC Name:
- Tris(2-ethylhexyl) phosphate
- Cas Number:
- 78-42-2
- Molecular formula:
- C24H51O4P
- IUPAC Name:
- tris(2-ethylhexyl) phosphate
- Details on test material:
- Mol wt: 434.6;
Sp g: 0.925 at 20 C;
n25D: 1.4473;
Surface tension: 31 dynes/sq cm;
Viscosity: 10.2 cp;
Vap press: 2 mm Hg at 200 C
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: no data
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- ca. 4 h
- Remarks on duration:
- Durations from 30 minutes up to 210 minutes were tested.
- Concentrations:
- 298, 287, 283, 452, 457, 447 mg/m³ air
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- > 447 mg/m³ air
- Exp. duration:
- 4 h
Any other information on results incl. tables
Results:
| Species: rats (mortalities/No Total) | Concentration (mg/m³ air) | Duration (min) | Product (mg min) |
| 0/10 | 298 | 60 | 17900 |
| 0/10 | 287 | 120 | 34400 |
| 0/10 | 283 | 180 | 51000 |
| 0/10 | 452 | 150 | 67800 |
| 0/10 | 457 | 180 | 82200 |
| 0/10 | 447 | 210 | 93800 |
Applicant's summary and conclusion
- Executive summary:
In an old and limited documented acute inhalation toxicity study in Wistar rats, the animals in groups of ten each were given single exposures of test substance aerosol having a mass medium diameter of 1.5µ. The concentrations given were followed: 298 (60min), 287 (120 min), 283 (180 min), 452 (150 min), 457 (180 min), 447 mg/m³ air (210 min). No mortalities were observed and therefore the LC50 was >447 mg/m³ air.
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