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EC number: 203-489-0 | CAS number: 107-41-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- sub-chronic toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- This study is considered invalid due to the high incidence of death due to respiratory infection in all test groups. Also the method of application was unusual and the actual dose level could not be accurately determined. There was potential for ingestion as the site of application was uncovered abdominal skin.
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- SIDS Initial Assessment Report for SIAM 13
- Author:
- OECD
- Year:
- 2 001
- Bibliographic source:
- UNEP PUBLICATIONS
- Reference Type:
- review article or handbook
- Title:
- Toxicity profile Hexylene glycol.
- Author:
- British Industrial Biological Research Association (BIBRA)
- Year:
- 1 991
- Reference Type:
- review article or handbook
- Title:
- Chapter Fifty. Glycols
- Author:
- Rowe VK and Wolf MA
- Year:
- 1 981
- Bibliographic source:
- Patty's Industrial Hygiene and Toxicology. Third Revised Edition. Clayton GD and Florence FE (Eds). John Wiley & Sons, New York.
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 950
- Report date:
- 1950
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 2-methylpentane-2,4-diol
- EC Number:
- 203-489-0
- EC Name:
- 2-methylpentane-2,4-diol
- Cas Number:
- 107-41-5
- Molecular formula:
- C6H14O2
- IUPAC Name:
- 2-methylpentane-2,4-diol
- Test material form:
- other: liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- male
Administration / exposure
- Type of coverage:
- open
- Vehicle:
- unchanged (no vehicle)
- Details on exposure:
- Repeated uncovered applications, 5 days/week for 90 applications. Groups of 10-12 rabbits were exposed at each dose level. The test material was gently rubbed into the clipped belly of each rabbit for 1 minute in every 15 minutes over a period of 1 hour. At the end of this time excess liquid was blotted off. The initial dose levels were 1 ml/kg and 2 ml/kg/day. The control animals received glycerol at 2 ml/kg. Due to mortality, unrelated to treatment, a second study was started using hexylene glycol at 1.0 and 0.5 ml/kg/day and glycerol at 1.0 ml/kg/day.
- Duration of treatment / exposure:
- 15 weeks
- Frequency of treatment:
- 5 days/week
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
0.5, 1.0 and 2.0 ml/kg bw/d
Basis:
nominal per unit area
- Remarks:
- Doses / Concentrations:
461, 923 and 1846 mg/kg bw/d
Basis:
other: Assuming a density of 923 mg/cm3
- No. of animals per sex per dose:
- 10-12
- Control animals:
- other: glycerol
- Details on study design:
- Post-exposure period: none
Examinations
- Sacrifice and pathology:
- Sections of skin from the treatment site plus liver and kidney were examined microscopically.
Results and discussion
Results of examinations
- Details on results:
- In the first experiment 2/11 rats receiving 2 ml/kg and 8/10 rats given 1 ml/kg hexylene glycol died due to respiratory infection or diarrhoea. 5 survivors at the higher dose level showed slight cloudy swelling of the liver. The two survivors at 1 ml/kg/day showed no histopathological changes in the liver or kidneys. 8/12 rabbits receiving glycerol also died. In the second study mortality was also high with 6/10 rabbits at 1 ml/kg and 4/11 at 0.5 ml/kg dying of lung infection. None of the survivors at 1 ml/kg showed any histopathological change in the liver or kidney. One survivor at 0.5 ml/kg showed cloudy swelling of the liver but the kidneys appeared normal. The effects on the skin were described as 'loss of epithelium and scrappy epidermis' for all treated and control groups. The authors considered this due to friction rather than a toxic effect.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- The study gives limited information concerning the effect of repeated inunction due to intercurrent infection amongst the test animals and the method of application. Changes in the skin at all dose levels were not attributed to the test compound. There were no effects considered treatment related at dose levels of 1 ml/kg/day.
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