2-methylpentane-2,4-diol

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1948

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

The work of this group pre-dates range finding toxicity guidelines and provided much of the basis for their development. Their results are cited by many subsequent authoritative review bodies and are often found in SIDS and SIAR documents via secondary references. Therefore, these results are deemed reliable.

Data source

Reference

Reference 1

Reference Type:

publication

Title:

FURTHER EXPERIENCE WITH THE RANGE FINDING TEST IN THE INDUSTRIAL TOXICOLOGY LABORATORY

Author:

Smyth HF & Carpenter CP

Year:

1948

Bibliographic source:

Journal of Industrial Hygiene and Toxicology Vol 30, no. 1, page 63-68

Reference 2

Reference Type:

publication

Title:

THE PLACE OF THE RANGE FINDING TEST IN THE INDUSTRIAL TOXICOLOGY LABORATORY

Author:

Smyth HF & Carpenter CP

Year:

1944

Bibliographic source:

J. IND. HYG. TOXICOL., 26, 269-273

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Deviations:

yes

Remarks:

Strain, sex, and no information of type of inhalation exposure or vehicle, no dose levels were reported, no information on animals or environmental conditions

GLP compliance:

no

Remarks:

study pre-dates GLP requirements

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-methylpentane-2,4-diol

EC Number:

203-489-0

EC Name:

2-methylpentane-2,4-diol

Cas Number:

107-41-5

Molecular formula:

C6H14O2

IUPAC Name:

2-methylpentane-2,4-diol

Details on test material:

- Name of test material (as cited in study report): 2-methyl pentane-2,4-diol

Test animals

Species:

rat

Strain:

not specified

Sex:

male

Details on test animals or test system and environmental conditions:

TEST ANIMALS
-No information reported

ENVIRONMENTAL CONDITIONS
-No information reported

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

not specified

Vehicle:

other: no data

Details on inhalation exposure:

Rats are exposed to a flowing stream of air substantially saturated with vapors of the test material, prepared by passing it through a fritted disc bubbler at room temperature for periods of time falling into a geometric series with a constant ratio of two, up to eight hours maximum.

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

8 h

Concentrations:

Concentrations used fall in a series differing by a ratio of 2, and they are approximations because they are estimated from the settings of a proportioning pump and flowmeter rather than being determined analytically.

No. of animals per sex per dose:

6

Control animals:

not specified

Details on study design:

Animals were observed for 14 days after adminstration

Statistics:

No information reported

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LC0

Effect level:

other: saturated vapor concentration

Based on:

test mat.

Exp. duration:

8 h

Remarks on result:

other: No mortality was observed

Mortality:

Not reported

Clinical signs:

other: Not reported

Body weight:

Not reported

Gross pathology:

Not reported

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

Maximum time for no death was reported to be 8 hours, concentration was not reported. LC50 > the saturated vapour concentration at room temperature.

Executive summary:

When groups of 6 rats were exposed for 8 hours to air saturated with hexylene glycol at room temperature (about 60 ml/m³), all animals survived without symptoms (no other details).