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EC number: 203-489-0 | CAS number: 107-41-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Additional information
Eye and respiratory tract irritation
Exposure of 12 male and 12 female test persons to hexylene glycol (HG) vapour in a concentration of 50 ppm (approximates the saturation concentration at 25°C) for 15 minutes caused eye irritation in most of the persons but no irritation of the nose or throat. The maximum tolerable concentration was considered to be 50 ppm (Silverman et al., 1946).
Skin sensitization
A study conducted in 823 eczema patients reported that HG used in patch testing (48 hour occlusive) at aqueous concentrations of 30 or 50% caused oedema and erythema of the skin in 2.8% of the patients tested (Kinnunen & Hannuksela, 1989). The authors considered this indicative of irritation due to application of HG. The authors studied also eczema patients with positive patch test reactions to 30 or 50% HG and found a positive ROAT (Repeated Open Application Test) in 1 of 7 patients. It was hypothesized tthat the reaction in this patient may be due to cross-sensitivity. Alomar et al, 1985 used HG (10% aqueous) as a standard patch test in a group of 230 patients exposed to cutting oils who had been diagnosed with occupational dermatitis. 9 patients gave a positive response to challenge with HG (3.9% of the total number tested).
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