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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2000
Report date:
2000

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 111 (Hydrolysis as a Function of pH)
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Cyclohex-1,4-ylenedimethanol
EC Number:
203-268-9
EC Name:
Cyclohex-1,4-ylenedimethanol
Cas Number:
105-08-8
Molecular formula:
C8H16O2
IUPAC Name:
cyclohexane-1,4-diyldimethanol
Details on test material:
- Name of test material (as cited in study report): 1,4-cyclohexanedimethanol
- Substance type: production sample
- Lot/batch No.: 33840
- Storage condition of test material: room temperature
Radiolabelling:
no

Study design

Analytical monitoring:
yes
Details on sampling:
An aliquot of each test system was removed at test intiation, 2.4 hours, and 120 hours and analyzed neat using high performance liquid chromatography with refractive index detection (HPLC/Rl) for percent hydrolysis. The date, time, appearance, pH, temperature of the water bath, and temperature of the room where the analysis was performed were recorded for each sample.
Buffers:
pH = 4 Buffer (0.01 M Sodium acetate)
Approximately 0.8 g of anhydrous sodium acetate was dissolved per liter of distilled water and the pH adjusted to approximately 4.0 with glacial acetic acid.

pH = 7 Buffer (0.02 M Phosphate buffer)
Approximately 1.4 g of potassium phosphate monobasic anhydrous and 1.7 g of potassium phosphate dibasic anhydrous were dissolved per liter of distilled water.

pH = 9 Buffer (0.025 M Sodium Borate buffer)
Approximately 9.5 g of sodium borate decahydrate were dissolved per liter of distilled water.
Details on test conditions:
PREPARATION OF TEST SOLUTIONS

Test systems were prepared by weighing approximately 0.1 g of the test substance into three separate 50-mL Erlenmeyer flasks. Each flask was diluted to 50 mL with one of the pH buffer solutions; pH 4, pH 7, or pH 9. Samples were removed and labeled "TO" (time O-hours). Each Erlenmeyer flask was then placed in a 50°C agitating water bath.
Duration of testopen allclose all
Duration:
0 h
pH:
3.62
Temp.:
50 °C
Initial conc. measured:
1 433 mg/L
Duration:
2.4 h
pH:
3.64
Temp.:
50 °C
Initial conc. measured:
1 441 mg/L
Duration:
120 h
pH:
3.65
Temp.:
50 °C
Initial conc. measured:
1 467 mg/L
Duration:
0 h
pH:
7.2
Initial conc. measured:
1.07 µg/L
Duration:
122 h
pH:
7
Temp.:
50 °C
Initial conc. measured:
1 390 µg/L
Duration:
0 h
pH:
9
Initial conc. measured:
1.57 mg/L
Duration:
2.4 h
pH:
7
Temp.:
50 °C
Initial conc. measured:
1 401 mg/L
Duration:
120 h
pH:
7
Temp.:
50 °C
Initial conc. measured:
1 464 mg/L
Duration:
0 h
pH:
9.2
Temp.:
50 °C
Initial conc. measured:
1 450 mg/L
Duration:
120 h
pH:
9.13
Temp.:
50 °C
Initial conc. measured:
1 601 mg/L
Number of replicates:
3
Positive controls:
no
Statistical methods:
Not performed due to lack of hydrolysis measured.

Results and discussion

Preliminary study:
The test substance does not readily hydrolyze in pH 4, pH 7, or pH 9 buffered systems. Less than 10 percent hydrolysis had occurred in each of the test systems at 120 hours at 50.0 ± 0.5 C, therfore no further testing (Test 1, Test 2, or Test 3) was required.
Transformation products:
no
Dissipation DT50 of parent compoundopen allclose all
Key result
pH:
4
Temp.:
50 °C
Remarks on result:
hydrolytically stable based on preliminary test
Key result
pH:
7
Temp.:
50 °C
Remarks on result:
hydrolytically stable based on preliminary test
Key result
pH:
9
Temp.:
50 °C
Remarks on result:
hydrolytically stable based on preliminary test

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
Results for the preliminary test suggest that little, if any, hydrolysis occurs at the pH range of 4 to 9.
Executive summary:

A preliminary hydrolysis test of 1,4-cyclohexanedimethanol was performed at pH values of 4, 7, and 9 at 50 °C.  The test substance systems were prepared by diluting approximately 0.1 g of the test substance into 50 mL of the pH buffers. The test solutions were analyzed for the test substance using high performance liquid chromatography with refractive index detection (HPLC/RI). The change in test substance concentration, over time, was calculated and reported as the percent hydrolysis. Less than 10 percent hydrolysis was observed in the pH 4, 7, and 9 test systems at 120 hours, therefore no further testing (Test 1, Test 2, or Test 3) was required.