Registration Dossier
Registration Dossier
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EC number: 601-093-6 | CAS number: 111453-32-8
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Tamip monoamide (ZK 39211) did not show any mutagenic potential in a bacterial reverse mutation assay with S. typhymurium (TA 1535, TA 100, TA 1537, TA 1538, TA 98) when tested up to 5.0 mg/plate in the absense and presense of intrinsic metabolic activation (liver mix from Aroclor 1254 -treated rats) (Schering AG, Report No. A483; 1993-06-28)
Tamip monoamide (ZK 39211) did not show any mutagenic potential in a bacterial reverse mutation assay with S. typhymurium (TA 1535, TA 100, TA 1537, TA 1538, TA 98) when tested with preincubation up to 5.0 mg/plate in the absense and presense of intrinsic metabolic activation (liver mix from Aroclor 1254 -treated rat) (Schering AG, Report No. A556; 1993-08-12)
Short description of key information:
Gene mutation (Bacterial reverse muation assay/AMES test, GLP): negative with and without metabolic activation
[Schering AG, Report No. A483; 1993-06-28]
Gene mutation (Bacterial reverse muation assay/AMES test, GLP): negative with and without metabolic activation
[Schering AG, Report No. A556; 1993-08-12]
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Tamip monoamide was tested in two standard genotoxicity tests and did not show any genotoxic potential. Thus, there is no sufficient evidence available to classify Tamip monoamide as genotoxic.
Tamip monoamide is not classified as genotoxic according to the German legislation (TRGS-905).
Classification according to Directive 67/548/EEC and Regulation (EC) 1272/2008 (CLP) is not required.
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