Registration Dossier
Registration Dossier
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EC number: 601-093-6 | CAS number: 111453-32-8
Endpoint summary
Administrative data
Description of key information
Dermal (Rat, GLP): non-skin irritant
[Schering AG, Report No. X192, 1997-01-08]
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
The single dermal administration of Tamip monoamide to male and female rats in the doses of 200 and 2000 mg/kg results at high dose in clinical signs in all male rats. One male rat died. The female animals were without any clinical signs. The test substance was tolerated without any local skin irritations. (Schering AG, Report No. X192, 1997-01-08)
Effects on eye irritation: corrosive
Justification for classification or non-classification
Tamip amide in aqueous suspensions is acidic (pH 1.5). Therefore, corrosive effects are expected in case Tamip monoamide is inadvertantly introduced into the eye.
According to Directive 67/548/EEC Tamip monoamide is classified as corrosive, caused severe burns (C; R35) .
According to Regulation 1272/2008/EC (CLP) the substance is classified as Category 1A, causes severe burns.
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