Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1993
Report Date:
1993

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
GLP compliance:
yes (incl. certificate)
Type of method:
shake-flask method to: flask method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
-3.7
Temp.:
25 °C
pH:
7

Any other information on results incl. tables

Table 1: analytical data of the partitioning experiment

Exp. no.

Cw (g/l)

Co (g/l)

Pow

1

2

3

6.407

5.241

5.970

1.23×10-3

1.05×10-3

1.08×10-3

    1.92×10-4

      2.01×10-4

      1.81×10-4

Applicant's summary and conclusion

Executive summary:

The partition equilibrium between n-octanol and aqueous buffer solutions (pH = 7) was determined by a modified flask shaking method in accordance with OECD Testing Guideline No. 107. Measurements on three aqueous solutions with different concentrations of ZK 39 211 and HPLC analysis of the concentration in the organic phase after equilibration gave a partition coefficient with 95 % confidence interval:

log Pow = - 3.72 +/- 0.03