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EC number: 939-464-2 | CAS number: 121617-08-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well documented publication which meets basic scientific principles
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Skin sensitizing properties of the ethanolamines mono-, di- and triethanolamine. Data analysis of a multicentre surveillance network (IVDK) and review of literature
- Author:
- Lessmann H, et al.
- Year:
- 2 009
- Bibliographic source:
- Contact Dermatitis, 60, 243-255
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Patch test results with TEA on patients collected from 1992 to 2007 were evaluated
- GLP compliance:
- no
Test material
- Reference substance name:
- triethanolamine
- IUPAC Name:
- triethanolamine
- Reference substance name:
- 2,2',2''-nitrilotriethanol
- EC Number:
- 203-049-8
- EC Name:
- 2,2',2''-nitrilotriethanol
- Cas Number:
- 102-71-6
- Molecular formula:
- C6H15NO3
- IUPAC Name:
- 2,2',2''-nitrilotriethanol
- Details on test material:
- - Name of test material (as cited in study report): Triethanolamine
- no further data given
Constituent 1
Constituent 2
Method
- Type of population:
- general
- Ethical approval:
- not specified
- Route of administration:
- dermal
Results and discussion
- Results of examinations:
- The positive reactions interpreted as allergic seem to be caused by exposure to TEA in cosmetics and/or topical therapeutic preparations possibly on damaged skin. The diagnosis of TEA contact sensitisation should therefore not be based on a positive patch test reaction alone but on a combination of history and ¿ preferably ¿ validation tests. The negative experimental findings in animals and the level of exposure to TEA in the population, the low frequency of positive reactions to low TEA concentrations in patch-tested patients indicates a very low sensitisation potential in humans, and the risk of sensitisation to TEA on uncompromised skin seems to be very low.
Any other information on results incl. tables
In total 85098 patients were tested with TEA. Of these 323 (0.35%) patients were tested positively to TEA. The reaction index was calculated to -0.49. Most of the reactions were weak positive reactions resulting in a high positive ratio (89.5%).
Frequencies of reactions to TEA in all patients tested from 1992 -2007
DEA (n = 85098) |
||
count |
[%] |
|
negative |
83830 |
98.5 |
irritant |
106 |
0.1 |
questionable |
773 |
0.9 |
follicular |
66 |
0.1 |
+ |
289 |
0.3 |
++ |
30 |
0.04 |
+++ |
4 |
0.005 |
reaction index |
-0.49 |
|
positivity ratio |
89.5% |
Regarding the MOAHLFA index, there were only minor differences between patients with positive and those without positive reactions to the diethanolamine.
MOAHLFA-Index Frequency of characteristics (%) in TEA-positive (cases) vs. non positive (controls) patients
TEA |
||
cases |
controls |
|
Men |
49.5 |
37.8 |
Occupational dermatitis |
23.2 |
15.5 |
Atopic dermatitis |
18.6 |
18.8 |
Hand dermatitis |
36.5 |
30.4 |
Leg dermatitis |
13.9 |
13.2 |
Face dermatitis |
16.7 |
16.1 |
Age ¿ 40 years |
69.0 |
64.7 |
Reactions to DEA and occupational exposure (metal workers)
If the prevalence of positive reactions in probably water-based metalworking fluids-exposed current male cutting workers is compared with the prevalence in all male patients not working in the metal industry at present, about five to sevenfold higher portion of positive reactions is recorded for MEA and DEA, respectively. For TEA, the prevalence is increased about three times with only 10 patients showing a (weakly) positive reaction.
Reactions to DEA associated with other (non-)occupational applications
In accordance with the unremarkable proportion of occupation-related cases, there were no distinctly different patterns of occupations inTEA-positive versus non-positive patients. There was no difference between the TEA-positive and theTEA non-positive subgroup of patients with regard to the frequencies of suspected causative exposures, such as a similar proportion of about 60% regarding presumable causation of contact dermatitis by cosmetics and topical therapeutics. The association between sporadic sensitization to TEA from exposure to cosmetics or topical
therapeutics is reflected by the high proportion of concomitant reactions to some substances, which are mainly used in these fields, that is fragrance mix (and Myroxylon pereirae), lanolin alcohol and cetearyl alcohol, and parabens. However, concomitant reactions indicating possibly
false-positive, irritant reactions have also been documented, for example for octyl gallate, phenyl mercuric acetate, propylene glycol, and cocamidopropyl betaine.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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