Registration Dossier
Registration Dossier
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EC number: 231-781-8 | CAS number: 7727-21-1
Carcinogenicity
Administrative data
Description of key information
The carcinogenic potential of dipotassium persulfate was assessed with a read across approach based on data from substances of the Persulfate Category. A study that examined carcinogenicity potential by dermal route was available for diammonium persulfate. Based on the assessment dipotassium persulfate was not considered carcinogenic.
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via dermal route
Link to relevant study records
- Endpoint:
- carcinogenicity: dermal
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Justification for type of information:
- READ ACROSS CATEGORY APPROACH
A category group was formed with dipotassium peroxodisulphate (KPS), disodium peroxodisulphate (SPS) and diammonium peroxodisulphate (APS). Several physico-chemical, fate, ecotoxicological and toxicological endpoints were assessed using the category approach. Please refer to the read across justification in chapter 13 for further information. - Reason / purpose for cross-reference:
- read-across source
- Key result
- Dose descriptor:
- NOAEL
- Sex:
- female
- Remarks on result:
- not determinable
- Remarks:
- no NOAEL identified. Effect type:carcinogenicity
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Justification for classification or non-classification
Substances of the Persulfate Category were not classified and labelled as carcinogenic according to Regulation 1272/2008/EC (CLP), as amended for the fifteenth time in Regulation (EU) 2020/1182, based on results obtained for substances of the Persulfate Category.
Additional information
Dipotassium persulfate of the Persulfate Category was not tested for carcinogenicity potential. As all substances of the Persulfate Category share the same anionic persulfate moiety and similar toxicological properties a read across approach was applied for dipotassium persulfate using results of a 51 weeks dermal carcinogenicity study in mice performed with another substance of the Persulfate Category, diammonium persulfate. Based on the results obtained with diammonium persulfate, dipotassium persulfate was considered not carcinogenic when applied to the skin.
Of the Persulfate Category, diammonium persulfate was tested for skin carcinogenicity potential. Based on the obtained results in a 51 week dermal study in mice, diammonium persulfate was not considered to be tumour promoter or a carcinogen when applied to the skin. As all substances of the Persulfate Category share the same anionic persulfate moiety and similar toxicological properties a read across was applied for dipotassium persulfate and disodium persulfate using results obtained with diammonium persulfate. No carcinogenesis potential was assumed for dipotassium persulfate and disodium persulfate.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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