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Key value for chemical safety assessment

Additional information

Dipotassium persulfate of the Persulfate Category was not tested for genetic toxicity. A read across approach was applied for dipotassium persulfate using results of in vitro and in vivo genetic toxicity testing obtained with another substance of the Persulfate Category, disodium persulfate as this substance shows similar toxicological properties. Based on the results obtained for disodium persulfate, no genetic toxicity was assumed for dipotassium persulfate. Of the Persulfate Category, disodium persulfate was tested for genetic toxicity in two in vitro tests and in two in vivo tests. Results of in vitro tests, an Ames test and an unscheduled DNA synthesis test with rat liver hepatocytes showed no signs of mutagenic activity. Results of in vivo tests with disodium persulfate showed no clastogenic effect in a mouse micronucleus test and no mutagenic activity in an in vivo unscheduled DNA synthesis assay in rat livers. Thus, disodium persulfate was considered not genotoxic. As all substances of the Persulfate Category share the same anionic persulfate moiety and similar toxicological properties a read across approach was applied for diammonium persulfate and dipotassium persulfate using results obtained with disodium persulfate. Diammonium persulfate and dipotassium persulfate were not considered genotoxic.

Short description of key information:
Dipotassium persulfate genetic toxicity was assessed following a read across approach on data from substances of the Persulfate Category. In vitro and in vivo test results were available for disodium persulfate. Dipotassium persulfate was not considered genotoxic.

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

Based on the results obtained, substances of the Persulfate Category were not classified and labelled for genetic toxicity according to Regulation (EC) No 1272/2008.