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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable publication
Cross-reference
Reason / purpose:
reference to same study

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Metabolism of Geraniol and Linalool in the Rat and effects on liver and Lung Microsomal Enzymes.
Author:
Chadha A, Madyastha M
Year:
1984
Bibliographic source:
Xenobiotica 14: 365-374
Reference Type:
secondary source
Title:
No information
Author:
Chadha A, Madyastha M
Year:
2008
Bibliographic source:
RIFM database

Materials and methods

Objective of study:
metabolism
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Geraniol
- Analytical purity: >99.5% pure,

Test animals

Species:
rat
Strain:
other: IISc strain
Sex:
male
Details on test animals and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 160 - 200 g
- Housing: after dosing individually
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
CMC (carboxymethyl cellulose)
Details on exposure:
VEHICLE
- Concentration: 1%
Duration and frequency of treatment / exposure:
20 days
Doses / concentrations
Remarks:
Doses / Concentrations:
800 mg/kg bw/d

Results and discussion

Metabolite characterisation studies

Metabolites identified:
yes
Details on metabolites:
geranic acid, 3-hydroxy-citronellic acid, 8-hydroxy-geraniol, 8-carboxy-geraniol
and dicarboxylic acid.

Applicant's summary and conclusion