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Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 231-102-5 | CAS number: 7439-93-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 994
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- not specified
Test material
- Reference substance name:
- lithium chloride and sodium hypochlorite generating lithium hypochlorite
- IUPAC Name:
- lithium chloride and sodium hypochlorite generating lithium hypochlorite
- Reference substance name:
- Lithium hypochlorite
- EC Number:
- 237-558-1
- EC Name:
- Lithium hypochlorite
- Cas Number:
- 13840-33-0
- Molecular formula:
- ClHO.Li
- IUPAC Name:
- lithium hypochlorite
Constituent 1
Constituent 2
- Radiolabelling:
- no
Test animals
- Species:
- other: humans
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- other: exposed in a spa ("bathing water" at 101+/-2°F equivalent to ca. 38.4°C)
- Vehicle:
- water
- Duration of exposure:
- 20 minutes/day, 4 days/week for two consecutive weeks
- Doses:
- ca. 40 mg lithium / L
- Control animals:
- yes
- Details on study design:
- Control spa: 0.02 ppm lithium
Results and discussion
- Signs and symptoms of toxicity:
- no effects
- Dermal irritation:
- no effects
Any other information on results incl. tables
There was no statistically significant difference in serum lithium levels between the control and treatment group at any stage. The pre-treatment levels of about 1 to max. 8 µg lithium / L serum were not exceeded after treatment.
Applicant's summary and conclusion
- Conclusions:
- Lithium ion is very unlikely to penetrate skin.
- Executive summary:
No significant elevation of serum lithium levels was reported in 53 healthy volunteers spending 20 minutes/day, 4 days/week for two consecutive weeks in a spa with a concentration of approximately 40 mg lithium / L as compared with unexposed controls. The study result confirms the very low skin absorption for inorganic lithium salts, as discussed in the key study.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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