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Diss Factsheets

Administrative data

Endpoint:
dermal absorption in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1994

Materials and methods

Test guideline
Qualifier:
no guideline followed
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
lithium chloride and sodium hypochlorite generating lithium hypochlorite
IUPAC Name:
lithium chloride and sodium hypochlorite generating lithium hypochlorite
Constituent 2
Chemical structure
Reference substance name:
Lithium hypochlorite
EC Number:
237-558-1
EC Name:
Lithium hypochlorite
Cas Number:
13840-33-0
Molecular formula:
ClHO.Li
IUPAC Name:
lithium hypochlorite
Radiolabelling:
no

Test animals

Species:
other: humans
Strain:
not specified
Sex:
male/female

Administration / exposure

Type of coverage:
other: exposed in a spa ("bathing water" at 101+/-2°F equivalent to ca. 38.4°C)
Vehicle:
water
Duration of exposure:
20 minutes/day, 4 days/week for two consecutive weeks
Doses:
ca. 40 mg lithium / L
Control animals:
yes
Details on study design:
Control spa: 0.02 ppm lithium

Results and discussion

Signs and symptoms of toxicity:
no effects
Dermal irritation:
no effects

Any other information on results incl. tables

There was no statistically significant difference in serum lithium levels between the control and treatment group at any stage. The pre-treatment levels of about 1 to max. 8 µg lithium / L serum were not exceeded after treatment.

Applicant's summary and conclusion

Conclusions:
Lithium ion is very unlikely to penetrate skin.
Executive summary:

No significant elevation of serum lithium levels was reported in 53 healthy volunteers spending 20 minutes/day, 4 days/week for two consecutive weeks in a spa with a concentration of approximately 40 mg lithium / L as compared with unexposed controls. The study result confirms the very low skin absorption for inorganic lithium salts, as discussed in the key study.