Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
dermal absorption in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1994

Materials and methods

Test guideline
Qualifier:
no guideline followed
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
lithium chloride and sodium hypochlorite generating lithium hypochlorite
IUPAC Name:
lithium chloride and sodium hypochlorite generating lithium hypochlorite
Constituent 2
Chemical structure
Reference substance name:
Lithium hypochlorite
EC Number:
237-558-1
EC Name:
Lithium hypochlorite
Cas Number:
13840-33-0
Molecular formula:
ClHO.Li
IUPAC Name:
lithium hypochlorite
Radiolabelling:
no

Test animals

Species:
other: humans
Strain:
not specified
Sex:
male/female

Administration / exposure

Type of coverage:
other: exposed in a spa ("bathing water" at 101+/-2°F equivalent to ca. 38.4°C)
Vehicle:
water
Duration of exposure:
20 minutes/day, 4 days/week for two consecutive weeks
Doses:
ca. 40 mg lithium / L
Control animals:
yes
Details on study design:
Control spa: 0.02 ppm lithium

Results and discussion

Signs and symptoms of toxicity:
no effects
Dermal irritation:
no effects

Any other information on results incl. tables

There was no statistically significant difference in serum lithium levels between the control and treatment group at any stage. The pre-treatment levels of about 1 to max. 8 µg lithium / L serum were not exceeded after treatment.

Applicant's summary and conclusion

Conclusions:
Lithium ion is very unlikely to penetrate skin.
Executive summary:

No significant elevation of serum lithium levels was reported in 53 healthy volunteers spending 20 minutes/day, 4 days/week for two consecutive weeks in a spa with a concentration of approximately 40 mg lithium / L as compared with unexposed controls. The study result confirms the very low skin absorption for inorganic lithium salts, as discussed in the key study.