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EC number: 231-102-5 | CAS number: 7439-93-2
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
In a 21-day semi-static chronic toxicity
test to Daphnia magna with lithium, the 21-day No Observed Effect
Concentration (NOEC) value and the Lowest Observed Effect Concentration
(LOEC) value, related to reproduction were 1.70 mg/L and 2.53 mg/L
respectively. The 21-day EC50 value was determined to be higher than
1.70 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 1.7 mg/L
Additional information
The purpose of the study was to evaluate the
influence of the test item lithium on the reproductive output of Daphnia
magna in a semi-static test system according to OECD Guideline 211.
Young female Daphnia (the parent animals) aged less than 24 hours at the
start of the test were exposed to aqueous test media containing the test
item for 21 days at a range of concentrations. The nominal test item
concentrations were 0.50, 0.75, 1.13, 1.70, 2.53, 3.80 and
5.70 mg lithium/L. The parallel running analytical determinations
confirmed that the test item concentrations examined (lowest and highest
test concentrations) remained within the range of ± 20 % of the nominal
and of the initial concentrations (varied between 98 and 117 per cent of
the nominal concentration); thus, all results were based on the nominal
test item concentrations.
In the three highest tested concentrations (2.53, 3.80 and 5.70 mg/L)
all parent animals died by the 13th day of the test without producing
any offspring. Therefore the results of these concentrations were
excluded from the data analysis related to the reproductive output. In
the control group two parent animals (20 %) died during the test which
was within the acceptable validity criteria. In the concentration range
of 0.50 – 1.70 mg/L mortality of parent animals was not observed during
the experiment. The reproduction was not reduced statistically
significantly in the concentration range of 0.50 – 1.70 mg/L compared to
the untreated control group. During the evaluation of the body length of
parent animals at the end of the test, statistically significant
difference was not observed in the remained living parent daphnids (in
the concentration range of 0.50 – 1.70 mg/L) compared to the control
group. Aborted broods, presence of male neonates or ephippia were not
noticed during the test.
Accordingly, the 21-day NOEC value related to reproduction was
determined to be 1.70 mg/L and the LOEC value as 2.53 mg/L. The obtained
results were not sufficient for an exact EC50 value estimation. The
21-day EC50 was determined to be higher than 1.70 mg/L.
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