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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Repeated dose toxicity: oral

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Administrative data

Endpoint:
short-term repeated dose toxicity: oral
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Meets generally accepted scientific standards, sufficiently documented.

Data source

Reference
Reference Type:
publication
Title:
Biochemical changes in brain in methanol poisoning--an experimental study.
Author:
Rao, K.R. et al.
Year:
1977
Bibliographic source:
Indian J Med Res 65(2): 285-292

Materials and methods

Principles of method if other than guideline:
Daily application of a single dose of methanol to monkeys by gavage over a period of 3 days.
GLP compliance:
not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Methanol
EC Number:
200-659-6
EC Name:
Methanol
Cas Number:
67-56-1
Molecular formula:
CH4O
IUPAC Name:
methanol
Details on test material:
- Name of test material (as cited in study report): methanol
- Analytical purity: no data

Test animals

Species:
monkey
Strain:
not specified
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Details on oral exposure:
VEHICLE
- Concentration in vehicle: 30 % solution
- Amount of vehicle (if gavage): no data
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
3 days
Frequency of treatment:
daily
Doses / concentrations
Remarks:
Doses / Concentrations:
2340 mg/kg bw
Basis:
actual ingested
No. of animals per sex per dose:
7 males
Control animals:
not specified

Results and discussion

Effect levels

Dose descriptor:
LOAEL
Effect level:
2 340 mg/kg bw/day (actual dose received)
Sex:
male
Basis for effect level:
other: mortality

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

2340 mg/kg bw was the lethal dose for all 7 animals under test after 3 days.

Applicant's summary and conclusion