Registration Dossier
Registration Dossier
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EC number: 204-468-9 | CAS number: 121-43-7
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- No data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards with acceptable restrictions.
Data source
Reference
- Reference Type:
- publication
- Title:
- Boric acid ointment: A study of possible intoxication in the treatment of burns.
- Author:
- Pfeiffer CC, Hallman LF & Gersh I.
- Year:
- 1 945
- Bibliographic source:
- J. Amer. Med. Assoc. 128 (4) 266 - 274.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: No data
- Deviations:
- not specified
- Principles of method if other than guideline:
- No data
- GLP compliance:
- no
- Remarks:
- Study pre-dates GLP
- Limit test:
- no
Test material
- Reference substance name:
- boric acid ointment
- IUPAC Name:
- boric acid ointment
- Details on test material:
- - Name of test material: Boric acid
- Molecular formula: H3BO3
- Molecular weight: 61.8
- Smiles notation:B(OH)3
- Substance type: Inorganic
- Physical state: Solid
- Analytical purity: > 99.9 % w/w
- Stability under test conditions: Stable
- Other: White and odourless.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intravenous
- Vehicle:
- not specified
- Doses:
- No data
- No. of animals per sex per dose:
- 40 animals
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 1 330 mg/kg bw
- Based on:
- test mat.
- Clinical signs:
- The pre-lethal symptom in these animals was depression.
Applicant's summary and conclusion
- Conclusions:
- The LD50 in rats was 1330 mg/kg bw. The pre-lethal symptom in these animals was depression.
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